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Gibco™ PeproGMP® Human Heregulin beta-1 Recombinant Protein, PeproTech®

Catalog No. 01672624
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01672624 50 μg
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Catalog No. 01672624 Supplier Gibco™ Supplier No. GMP1000350UG
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Description

Recombinant Protein

Additional product information and specifications are provided on the Certificate of Analysis. All PeproGMP® products are manufactured using animal-derived component free materials. Product Description/Intended Use: PeproTech GMP recombinant proteins are manufactured for use as ancillary materials by applying applicable principles of GMP and quality control requirements from USP (United States Pharmacopeia) Chapter 1043 Ancillary Materials for Cell, Gene, and Tissue-Engineered Products. Product use statement: For research use or further manufacturing. Not for diagnostic use or direct administration into humans or animals.

Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development.

Specifications

Accession Number Q02297
For Use With (Application) Control, Western Blot Control, Bioactivity
Format Lyophilized
Formulation Protein with no preservative
Gene ID (Entrez) 3084
Molecular Weight (g/mol) 7.5 kDa
Name PeproGMP™ Human Heregulin beta-1
Purification Method Purified
Quantity 50 μg
Storage Requirements -20°C or -80°C if preferred
Regulatory Status GMP
Endotoxin Concentration ≤0.1 EU/μg
Gene Alias 6030402G23Rik; acetylcholine receptor-inducing activity; ARIA; Breast cancer cell differentiation factor p45; D230005F13Rik; GGF; GGF2; GGFII; Glial growth factor; glial growth factor 2; heregulin; heregulin, alpha (45kD, ERBB2 p185-activator); Hgl; HRG; HRG1; HRGA; HRGalpha; MST131; MSTP131; NDF; Neu differentiation factor; neuregulin 1; neuregulin 1 type III beta 3; Neuregulin-1; Nrg1; NRG1-IT2; Pro-neuregulin-1, membrane-bound isoform; pro-NRG1; sensory and motor neuron derived factor; Sensory and motor neuron-derived factor; SMDF; type I neuregulin 1; type III neuregulin 1
Common Name HRG beta-1
Gene Symbol Nrg1
Biological Activity Determined by proliferation of human MCF-7 cells.
Product Type Protein
Conjugate Unconjugated
Recombinant Recombinant
Sequence SHLVKCAEKE KTFCVNGGEC FMVKDLSNPS RYLCKCPNEF TGDRCQNYVM ASFYKHLGIE FMEAE
Content And Storage -20°Cor to +80°C if preferred
Activity Determined by proliferation of human MCF-7 cells.
Expression System E. coli
Form Lyophilized
Purity or Quality Grade ≥ 98% by SDS-PAGE gel and HPLC analyses.
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