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Gibco™ PeproGMP® Human Flt-3 Ligand (FLT3L) Recombinant Protein, PeproTech®

Catalog No. 01672637
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50 μg
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Catalog No. Quantity
01672637 50 μg
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Catalog No. 01672637 Supplier Gibco™ Supplier No. GMP3001950UG
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Description

Recombinant Protein

Multiple isoforms of Flt3-Ligand have been identified. The predominant biologically active form is anchored to the cell surface as the extracellular domain of a transmembrane protein (209 a.a.). The membrane-bound isoform can be proteolytically cleaved to generate a biologically active soluble isoform. Additional product information and specifications are provided on the Certificate of Analysis. All PeproGMP® products are manufactured using animal-derived component free materials. Product Description/Intended Use: PeproTech GMP recombinant proteins are manufactured for use as ancillary materials by applying applicable principles of GMP and quality control requirements from USP (United States Pharmacopeia) Chapter 1043 Ancillary Materials for Cell, Gene, and Tissue-Engineered Products. Product use statement: For research use or further manufacturing. Not for diagnostic use or direct administration into humans or animals.

FLT3LG (Fms Related Tyrosine Kinase 3 Ligand) is a Protein Coding gene. Diseases associated with FLT3LG include Aplastic Anemia and Brain Cancer. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Ras signaling pathway. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and cytokine activity. Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8-positive classical DCs and their CD103-positive tissue counterparts.

Specifications

Accession Number P49771
For Use With (Application) Control, Western Blot Control, Bioactivity
Format Lyophilized
Formulation Protein with no preservative
Gene ID (Entrez) 2323
Molecular Weight (g/mol) 17.6 kDa
Name PeproGMP™ Human Flt-3 Ligand (FLT3L)
Purification Method Purified
Quantity 50 μg
Storage Requirements -20°C or -80°C if preferred
Regulatory Status GMP
Endotoxin Concentration ≤0.1 EU/μg
Gene Alias FL; Flt 3 ligand; Flt3; Flt3 L; Flt3 ligand; Flt3l; Flt3lg; fms related receptor tyrosine kinase 3 ligand; fms related tyrosine kinase 3 ligand; FMS-like tyrosine kinase 3 ligand; fms-related tyrosine kinase 3; fms-related tyrosine kinase 3 ligand; H-FLT-3-L; Ly72L; M-FLT-3-L; NEWGENE_2322792; SL cytokine
Common Name FLT3LG
Gene Symbol FLT3LG
Biological Activity Determined by its ability to stimulate human AML5 cell proliferation. PeproGMP Recombinant Human Flt3-Ligand has been tested against the WHO standard NIBSC 96/532.
Product Type Protein
Conjugate Unconjugated
Recombinant Recombinant
Sequence MTQDCSFQHS PISSDFAVKI RELSDYLLQD YPVTVASNLQ DEELCGGLWR LVLAQRWMER LKTVAGSKMQ GLLERVNTEI HFVTKCAFQP PPSCLRFVQT NISRLLQETS EQLVALKPWI TRQNFSRCLE LQCQPDSSTL PPPWSPRPLE ATAPTA
Content And Storage -20°Cor to +80°C if preferred
Activity Determined by its ability to stimulate human AML5 cell proliferation. PeproGMP Recombinant Human Flt3-Ligand has been tested against the WHO standard NIBSC 96/532. Find the International Unit (IU) value <a href='https://www.thermofisher.com/us/en/home/life-science/cell-culture/cell-culture-learning-center/recombinant-protein-information/international-units.html'>here</a>.
Expression System E. coli
Form Lyophilized
Purity or Quality Grade ≥ 98% by SDS-PAGE gel and HPLC analyses.
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