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Invitrogen™ PDE12 Polyclonal Antibody
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Catalog No. PIPA5116741
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100 μL
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PIPA5116741 100 μL
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Catalog No. PIPA5116741 Supplier Invitrogen™ Supplier No. PA5116741
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Description

Rabbit Polyclonal Antibody

Positive Samples: Mouse thymus, Rat thymus Immunogen sequence: AVEKLSRAEA GSQTAAGAME RAVVRCVPSE PKLSLSFALA DGSHKNMQRD QSEPLGRVLS RIATNALKGH AKAAAAKKSR KSRPNASGGA ACSGPGPEPA VFCEPVVKLY YREEAVAEDV LNVDAWQDGA VLQIGDVKYK VERNPPAFTE LQLPRYIMAG FPVCPKLSLE FGDPASSLFR WYKEAKPGAA EPEVGVPSSL SPSSPSSSWT ETDVEERVYT PSNADIGLRL KLHCTPGDGQ RFGHSRELES VCVVEAGPGT CTFDHRHLYT KKVTEDALIR TVSY.

PDE12 is an enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. It also cleaves 3',5'-phosphodiester bond of oligoadenylates and plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.

Specifications

Antigen PDE12
Applications ELISA, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1.3 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene PDE12
Gene Accession No. Q3TIU4, Q6AXQ5
Gene Alias 2',5'-phosphodiesterase 12; 2',5'-phosphodiesterase 12-like protein; 2'-PDE; 2-PDE; 2'-phosphodiesterase; E430028B21Rik; fc58c05; fi42f03; LOC558284 protein; LOW QUALITY PROTEIN: 2',5'-phosphodiesterase 12; LRRGT00074; Mitochondrial deadenylase; PDE12; phosphodiesterase 12; RGD1310975; wu:fc58c05; wu:fi42f03; zgc:136374
Gene Symbols PDE12
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 17-300 of human PDE12 (NP_0013091061).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 211948, 306231
Target Species Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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