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Invitrogen™ PDCL3 Polyclonal Antibody

Description
Immunogen sequence: EWNDILRKKG ILPPKESLKE LEEEAEEEQR ILQQSVVKTY EDMTLEELED HEDEFNEEDE RAIEMYRRRR LAEWKATKLK Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 85%.
Phosducin-like proteins (PhLPs) are a conserved family of proteins with thioredoxin-like domains that were initially identified as modulators of G protein signaling. PDCL3 is highly homologous to PDCL and shares an N-terminal helix domain and a C-terminal thioredoxin-fold (Trx-fold) domain. Along with the related protein PDCL2, PDCL3 interacts with the chaperonin CCT and modulates CCT-mediated actin and tubulin folding. Modulation of PDCL3 levels by MAPK phosphorylation and RhoA-dependent changes also promote cytoskeletal remodeling.
Specifications
Specifications
| Antigen | PDCL3 |
| Applications | Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry |
| Classification | Polyclonal |
| Concentration | 0.2 mg/mL |
| Conjugate | Unconjugated |
| Formulation | PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 |
| Gene | PDCL3 |
| Gene Accession No. | Q4KLJ8, Q8BVF2, Q9H2J4 |
| Gene Alias | 1110061A19Rik; C80025; HTPHLP; IAP-associated factor VIAF1; PDCL3; PhLP2A; PHLP3; phosducin like 3; phosducin-like 3; phosducin-like protein 3; PhPL3; VIAF; VIAF1; VIAF-1; Viral IAP-associated factor 1 |
| Gene Symbols | PDCL3 |
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