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Invitrogen™ PD-L1 (CD274) Chimeric Recombinant Human Monoclonal Antibody (XGMHc25.1)
Human Recombinant Monoclonal Antibody
Supplier: Invitrogen™ MA551621
Description
This antibody binds human PD-L1.
Programmed death receptor ligand 1 (PD-L1, also called B7-H1) is a recently described B7 family member. To date, one specific receptor has been identified that can be ligated by PD-L1. This receptor, programmed death receptor 1 (PD-1), has been shown to negatively regulate T-cell receptor (TCR) signaling. Upon ligating its receptor, PD-L1 has been reported to decrease TCR-mediated proliferation and cytokine production. PD-L1 expression was found to be abundant on many murine and human cancers and could be further up-regulated upon IFN-gamma stimulation. Thus, PD-L1 might play an important role in tumor immune evasion.Specifications
| PD-L1 (CD274) Chimeric | |
| Recombinant Monoclonal | |
| 1 mg/mL | |
| PBS with 0.02% ProClin 300 | |
| Q9NZQ7 | |
| Cd274 | |
| The original antibody was generated by immunizing BALB/c mice with a human B7-H1 fusion protein. | |
| 200 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG1 κ |
| Flow Cytometry, Immunohistochemistry | |
| XGMHc25.1 | |
| Unconjugated | |
| Cd274 | |
| A530045L16Rik; B7 homolog 1; B7-H; B7h1; B7-H1; Cd274; CD274 antigen; CD274 molecule; PDCD1 ligand 1; Pdcd1l1; Pdcd1lg1; Pdl1; PD-L1; pdl-1; Programmed cell death 1 ligand 1; programmed death ligand 1; RGD1566211; sCD274; soluble CD274; soluble PD L1; sPD L1 | |
| Human | |
| Protein A | |
| RUO | |
| 29126 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |