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Orlistat, 98%

Catalog No. aaj62999mf
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Catalog No. AAJ62999MF Supplier Thermo Scientific Chemicals Supplier No. J62999MF
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Description

CAS: 96829-58-2 | C29H53NO5 | 495.75 g/mol

Orlistat, used in obesity research, is a pancreatic lipase inhibitor that acts locally in the gastrointestinal tract to inhibit lipase. More detailed experiments show that gradually THL affects the retinoblastoma protein pathway and leads to cell-cycle arrest at G1/S boundary. Lipase Inhibitor, THL is an inhibitor of pancreatic and gastric lipase, as well as carboxyl ester lipase (CEL) and diacylglycerol lipase-α (DAGLα). Lipase Inhibitor, THL also activates caspase-3.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Orlistat, used in obesity research, is a pancreatic lipase inhibitor that acts locally in the gastrointestinal tract to inhibit lipase. More detailed experiments show that gradually THL affects the retinoblastoma protein pathway and leads to cell-cycle arrest at G1/S boundary. Lipase Inhibitor, THL is an inhibitor of pancreatic and gastric lipase, as well as carboxyl ester lipase (CEL) and diacylglycerol lipase-α (DAGLα). Lipase Inhibitor, THL also activates caspase-3.

Solubility
Soluble in DMSO (19 mg/mL), ethanol (20 mg/mL), and DMF (20 mg/mL).

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C. Keep away from strong oxidizing agents.

Chemical Identifiers

CAS 96829-58-2
Molecular Formula C29H53NO5
Molecular Weight (g/mol) 495.75
MDL Number MFCD05662360
InChI Key AHLBNYSZXLDEJQ-FWEHEUNISA-N
Synonym orlistat, tetrahydrolipstatin, xenical, alli, orlipastat, --tetrahydrolipstatin, orlipastatum, orlipastatum inn-latin, thlp, tetrahydrolipastatin
PubChem CID 3034010
IUPAC Name (2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-2-yl (2S)-2-formamido-4-methylpentanoate
SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](CC(C)C)NC=O

Specifications

Melting Point <50°C
Color White
Quantity 50 mg
Merck Index 14,6869
Solubility Information Soluble in DMSO (19mg/mL),ethanol (20mg/mL),and DMF (20mg/mL).
Formula Weight 495.73
Percent Purity 98%
Physical Form Solid
Chemical Name or Material Orlistat

Safety and Handling

RTECSNumber OH3167600
TSCA No
Recommended Storage Store at -20°C

RUO – Research Use Only