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  6. Invitrogen™ NUMB Recombinant Rabbit Monoclonal Antibody (23GB1070)

Invitrogen™ NUMB Recombinant Rabbit Monoclonal Antibody (23GB1070)
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Catalog No. MA554048
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100 μL
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MA554048 100 μL
MA554049 20 μL
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Catalog No. MA554048 Supplier Invitrogen™ Supplier No. MA554048
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Description

Rabbit Recombinant Monoclonal Antibody

NUMB Recombinant Monoclonal Antibody for Flow, ICC/IF, Western Blot

Protein NUMB homolog is an evolutionarily conserved protein that controls the differentiation of neuronal progenitor cells. Recent studies have revealed that NUMB functions in clathrin-dependent endocytosis by binding to the AP-2 complex. NUMB is also expressed in postmitotic neurons and plays a role in axonal growth. Neural cells expressing Numb isoforms with short phosphotyrosine-binding (SPTB) domain undergo extensive neurite outgrowth, an effect that can be blocked by voltage-gated Ca2+ channel (VGCC) inhibitor or by Ca2+ chelator.

Specifications

Antigen NUMB
Applications Flow Cytometry, Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone 23GB1070
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Numb
Gene Accession No. P49757, Q2LC84, Q9QZS3
Gene Alias c14_5527; C14orf41; h-Numb; mnb; m-Nb; m-numb; Nb; NUMB; NUMB endocytic adaptor protein; numb gene homolog; numb gene homolog (Drosophila); numb homolog; numb homolog (Drosophila); NUMB isoform 3; Numb variant 1; Numb variant 2; NUMB, endocytic adaptor protein; protein numb homolog; Protein S171; PTB domain protein; S171
Gene Symbols Numb
Host Species Rabbit
Immunogen A synthetic peptide of human NUMB (413-651AA).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18222, 29419, 8650
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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