Invitrogen™ NTSR2 Polyclonal Antibody

Description

PA3-300 detects neurotensin receptor NTS2 from human samples. PA3-300 has been successfully used in Western blot and immunohistochemistry (paraffin) procedures. By Western blot this antibody detects a ~55-60 kDa protein representing NTS2 receptor. The PA3-300 immunogen is a synthetic peptide corresponding to residues P(381) Q S P T L M D T A S G F G D P P E T R T(401) of human NTS2 receptor.

The protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist.