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Invitrogen™ NSUN2 Polyclonal Antibody
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Catalog No. pipa5115674
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PIPA5115674 100 μL
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Catalog No. PIPA5115674 Supplier Invitrogen™ Supplier No. PA5115674
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total NSUN2.

NSUN2 encodes a methyltransferase that catalyzes the intron-dependent formation of 5-methylcytosine at C34 of tRNA-leu(CAA). Maturation of cytoplasmic tRNAs includes splicing of introns, which are located 1 nucleotide 3-prime from the anticodon in all intron-containing tRNA genes. In tRNA-leu(CAA), the first position of the anticodon, C34, is converted to 5-methylcytosine, a modification necessary to stabilize the anticodon-codon pairing and correctly translate the mRNA. Mutations of NSUN2 result in autosomal recessive 5 mental retardation (MRT5).

Specifications

Antigen NSUN2
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide
Gene NSUN2
Gene Accession No. Q08J23, Q1HFZ0
Gene Alias 5-methycytoisine methyltransferase; D13Wsu123e; hTrm4; Misu; mRNA cytosine C(5)-methyltransferase; MRT5; Myc-induced SUN domain containing protein; myc-induced SUN domain-containing protein; Myc-induced SUN-domain-containing protein; NOL1/NOP2/Sun domain family 2; NOL1/NOP2/Sun domain family member 2; NOL1/NOP2/Sun domain family, member 2; NOP2/Sun domain family, member 2; NOP2/Sun RNA methyltransferase family member 2; NOP2/Sun RNA methyltransferase family, member 2; Nsun2; RGD1311954; RNA cytosine C(5)-methyltransferase NSUN2; SAKI; substrate of AIM1/Aurora kinase B; TRM4; tRNA (cytosine(34)-C(5))-methyltransferase; tRNA (cytosine-5-)-methyltransferase NSUN2; tRNA cytosine C(5)-methyltransferase; tRNA methyltransferase 4 homolog
Gene Symbols NSUN2
Host Species Rabbit
Immunogen A synthesized peptide derived from human NSUN2(Accession Q08J23), corresponding to amino acid residues P504-E554.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 28114, 361191, 54888
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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