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  6. Invitrogen™ NSMCE1 Monoclonal Antibody (K56018_3A9), Invitrogen™

Invitrogen™ NSMCE1 Monoclonal Antibody (K56018_3A9), Invitrogen™

Catalog No. MA556280
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200 μL
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MA556280 200 μL
MA555900 50 μL
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Catalog No. MA556280 Supplier Invitrogen™ Supplier No. MA556280
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Description

Mouse Monoclonal Antibody

Sequence of this protein is as follows: MQGSTRRMGV MTDVHRRFLQ LLMTHGVLEE WDVKRLQTHC YKVHDRNATV DKLEDFINNI NSVLESLYIE IKRGVTEDDG RPIYALVNLA TTSISKMATD FAENELDLFR KALELIIDSE TGFASSTNIL NLVDQLKGKK MRKKEAEQVL QKFVQNKWLI EKEGEFTLHG RAILEMEQYI RETYPDAVKI CNICHSLLIQ GQSCETCGIR MHLPCVAKYF QSNAEPRCPH CNDYWPHEIP KVFDPEKERE SGVLKSNKKS LRSRQH

The NSMCE1 (Non-SMC Element 1 Homolog) gene encodes a protein that is a key component of the SMC5-SMC6 complex, which is essential for DNA repair and the maintenance of genomic stability. Located on chromosome 16, the NSMCE1 protein interacts with other components of the SMC5-SMC6 complex, including SMC5, SMC6, and NSMCE2, facilitating the repair of DNA double-strand breaks and promoting chromosome segregation during cell division. NSMCE1 is particularly involved in homologous recombination, a critical pathway for error-free DNA repair. Mutations or deficiencies in NSMCE1 can lead to genomic instability, increased sensitivity to DNA-damaging agents, and have been associated with several genetic disorders and cancer predispositions.

Specifications

Antigen NSMCE1
Applications Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Classification Monoclonal
Clone K56018_3A9
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol, 0.5% BSA and 0.09% sodium azide
Gene NSMCE1
Gene Accession No. Q8WV22
Gene Alias 2510027N19Rik; HSPC333; HSPC337; Non-SMC element 1 homolog; non-SMC element 1 homolog (S. cerevisiae); non-structural maintenance of chromosomes element 1 homolog; NSE1; NSE1 homolog, SMC5-SMC6 complex component; Nsmce1; RGD1307760
Gene Symbols NSMCE1
Host Species Mouse
Immunogen Recombinant human NSMCE1 (immunogen range is 1-266).
Purification Method Protein A
Quantity 200 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 197370
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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