Invitrogen™ NSMCE1 Monoclonal Antibody (K56018_3A9), Invitrogen™

Description

Sequence of this protein is as follows: MQGSTRRMGV MTDVHRRFLQ LLMTHGVLEE WDVKRLQTHC YKVHDRNATV DKLEDFINNI NSVLESLYIE IKRGVTEDDG RPIYALVNLA TTSISKMATD FAENELDLFR KALELIIDSE TGFASSTNIL NLVDQLKGKK MRKKEAEQVL QKFVQNKWLI EKEGEFTLHG RAILEMEQYI RETYPDAVKI CNICHSLLIQ GQSCETCGIR MHLPCVAKYF QSNAEPRCPH CNDYWPHEIP KVFDPEKERE SGVLKSNKKS LRSRQH

The NSMCE1 (Non-SMC Element 1 Homolog) gene encodes a protein that is a key component of the SMC5-SMC6 complex, which is essential for DNA repair and the maintenance of genomic stability. Located on chromosome 16, the NSMCE1 protein interacts with other components of the SMC5-SMC6 complex, including SMC5, SMC6, and NSMCE2, facilitating the repair of DNA double-strand breaks and promoting chromosome segregation during cell division. NSMCE1 is particularly involved in homologous recombination, a critical pathway for error-free DNA repair. Mutations or deficiencies in NSMCE1 can lead to genomic instability, increased sensitivity to DNA-damaging agents, and have been associated with several genetic disorders and cancer predispositions.