Nitrofurantoin is a nitrofuran antibiotic that is used as a substrate of bacterial nitrofuran reductase to study the interactions of active metabolites with DNA, ribosomal proteins and metabolic and pro-oxidant processes. It is an antibactericidal compound that has been historically prepared by the reaction of 1-aminohydantoin sulfate and 5-nitro-2-furaldehyde diacetate. It shows activity against many Gram-positive and Gram-negative bacteria. Nitrofurantoin is effective against enterococci, staphylococci, streptococci, corneybacteria, many strains of Escherichia coli.
Soluble in water (<0.01g/100mL at 19°C), dimethyl sulfoxide and methanol.
Keep container tightly sealed. Store in cool, dry conditions in well sealed containers. Store under dry inert gas. It is hygroscopic in nature. Incompatible with oxidizing agents. It is sensitive to light.
Safety and Handling
GHS H Statement
Toxic if swallowed.
May cause allergy or asthma symptoms or breathing difficulties if inhaled.
Suspected of causing genetic defects.
Suspected of causing cancer.
Suspected of damaging fertility or the unborn child.
May cause an allergic skin reaction.
GHS P Statement
Avoid breathing dust/fume/gas/mist/vapors/spray.
Wear protective gloves/protective clothing/eye protection/face protection.
IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
Store locked up.
Dispose of contents/container in accordance with local/regional/national/international regulations.
TSCA : TSCA