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PeproTech Neurturin Polyclonal Antibody, PeproTech®, Invitrogen™

Catalog No. 500P10250UG
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50 μg
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Catalog No. Quantity
500P10250UG 50 μg
500P102100 100 μg
500P1021MG 1 mg
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Catalog No. 500P10250UG Supplier PeproTech Supplier No. 500P10250UG

Description

Rabbit Polyclonal Antibody

AA Sequence of recombinant protein: ARLGARPCGL RELEVRVSEL GLGYASDETV LFRYCAGACE AAARVYDLGL RRLRQRRRLR RERVRAQPCC RPTAYEDEVS FLDAHSRYHT VHELSARECA CV. Preparation: Produced from sera of rabbits immunized with highly pure Recombinant Human Neurturin. Anti-Human Neurturin-specific antibody was purified by affinity chromatography employing an immobilized Human Neurturin matrix. Sandwich ELISA: To detect Human Neurturin by sandwich ELISA (using 100 μL/well antibody solution) a concentration of 0.5-2.0 μg/mL of this antibody is required. This antigen affinity purified antibody, in conjunction with PeproTech Biotinylated Anti-Human Neurturin (500-P102Bt) as a detection antibody, allows the detection of at least 0.2-0.4 ng/well of Recombinant Human Neurturin. Western Blot: To detect Human Neurturin by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2 μg/mL. Used in conjunction with compatible secondary reagents the detection limit for Recombinant Human Neurturin is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions.

Glial cell line-derived neurotrophic factor (GDNF) plays key roles in the control of vertebrate neuron survival and differentiation. A novel neurotrophic factor was recently cloned from human and mouse and designated neurturin. Physiological responses to neurturin (NTN) require the presence of receptor tyrosine kinase RET and a novel glycosylphosphatidylinositol linked receptor NTNRalpha. The cDNAs encoding NTNRalpha from human, rat, chicken, and mouse have been cloned recently and termed GDNFR-b, Ret ligand 2 (RETL2) or TGF-beta-related neurotrophic factor receptor 2 (TrnR2) and nominated as GFR-a-2 recently. NTN binds to and forms a complex with GFR-a-2 and the Ret PTK and activates the RET receptor tyrosine kinase pathway. Both NTN and GDNF can activate the MAP kinase and phosphatidylinositol 3-kinase pathways and play a critical role in the development of many neuronal populations. Neurturin and GDNF define a new family of neurotrophic factors.

Specifications

Antigen Neurturin
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.1-1.0 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene NRTN
Gene Accession No. Q99748
Gene Alias neurturin; NRTN; NTN; prepro-neurturin
Gene Symbols NRTN
Host Species Rabbit
Immunogen E.coli-derived Recombinant Human Neurturin.
Purification Method Antigen affinity chromatography
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4902
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Lyophilized
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