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Invitrogen™ NEDD4 Monoclonal Antibody (K24022_16E6), Invitrogen™
Mouse Monoclonal Antibody
Supplier: Invitrogen™ MA556193
Description
Sequence of this protein is as follows: NARLTIFGNS AVSQPASSSN HSSRRGSLQA YTFEEQPTLP VLLPTSSGLP PGWEEKQDER GRSYYVDHNS RTTTWTKPTV QATVETSQLT SSQSSAGPQS QASTSDSGQQ
The E3 ubiquitin-protein ligase NEDD4 is a Ubl conjugation pathway protein. It contains one HECT (E6AP-type E3 ubiquitin-protein ligase) domain and four WW domains. It is involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. It acts as a potential proto-oncogene that negatively regulates PTEN via ubiquitination, a paradigm analogous to that of Mdm2 and p53. It is also reported to be involved in the budding of many viruses and is the regulator of epithelial Na+ channels, which lead to arterial hypertension. NEDD4 protein is localized to the sarcolemmal region of muscle fibers. Increase in NEDD4 protein expression leads to unloaded and denervated muscles as well as a decrease in Notch1 expression. Hence it acts as down regulator of Notch-1 gene expression.Chemical Identifiers
| NEDD4 | |
| 1 mg/mL | |
| Monoclonal | |
| Liquid | |
| RUO | |
| PBS with 50% glycerol, 0.5% BSA and 0.09% sodium azide | |
| AA959633; AL023035; AU019897; cell proliferation-inducing gene 53 protein; E3 ubiquitin-protein ligase NEDD4; E430025J12Rik; HECT-type E3 ubiquitin transferase NEDD4; Kiaa0093; mKIAA0093; NEDD4; NEDD-4; NEDD4 E3 ubiquitin protein ligase; Nedd4-1; Nedd4a; Neural precursor cell expressed developmentally down-regulated protein 4; neural precursor cell expressed, developmentally down-regulated 4; neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase; neural precursor cell expressed, developmentally down-regulated gene 4; neural precursor cell expressed, developmentally down-regulated gene 4a; neural precursor cell expressed, developmentally down-regulted gene 4; OTTHUMP00000217840; OTTHUMP00000217841; OTTHUMP00000217842; PIG53; receptor-potentiating factor 1; RPF1 | |
| Recombinant human NEDD4 (immunogen range is 721-830). | |
| Primary | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| NEDD4 |
| K24022_16E6 | |
| Western Blot | |
| Unconjugated | |
| Mouse | |
| Human | |
| P46934 | |
| 4734 | |
| IgG1 | |
| Protein A | |
| Antibody |
Specifications
| NEDD4 | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with 50% glycerol, 0.5% BSA and 0.09% sodium azide | |
| P46934 | |
| NEDD4 | |
| Recombinant human NEDD4 (immunogen range is 721-830). | |
| 200 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG1 |
| Western Blot | |
| K24022_16E6 | |
| Unconjugated | |
| NEDD4 | |
| AA959633; AL023035; AU019897; cell proliferation-inducing gene 53 protein; E3 ubiquitin-protein ligase NEDD4; E430025J12Rik; HECT-type E3 ubiquitin transferase NEDD4; Kiaa0093; mKIAA0093; NEDD4; NEDD-4; NEDD4 E3 ubiquitin protein ligase; Nedd4-1; Nedd4a; Neural precursor cell expressed developmentally down-regulated protein 4; neural precursor cell expressed, developmentally down-regulated 4; neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase; neural precursor cell expressed, developmentally down-regulated gene 4; neural precursor cell expressed, developmentally down-regulated gene 4a; neural precursor cell expressed, developmentally down-regulted gene 4; OTTHUMP00000217840; OTTHUMP00000217841; OTTHUMP00000217842; PIG53; receptor-potentiating factor 1; RPF1 | |
| Mouse | |
| Protein A | |
| RUO | |
| 4734 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |