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Invitrogen™ NADK Polyclonal Antibody
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Catalog No. PIPA570657
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100 μL
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Catalog No. Quantity
PIPA570657 100 μL
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Catalog No. PIPA570657 Supplier Invitrogen™ Supplier No. PA570657

Description

Rabbit Polyclonal Antibody

This target displays homology in the following species: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 93%.

NADK (Nicotinamide Adenine Dinucleotide Kinase) is an enzyme crucial in the regulation of intracellular NADP+ levels, which are necessary for metabolic processes such as fatty acid and DNA synthesis. The human NADK gene is located on chromosome 1p36.33 and encodes a protein that primarily functions in the cytoplasm. NADK catalyzes the phosphorylation of NAD+ to NADP+, playing a significant role in maintaining the cellular redox state. Structurally, human NADK forms a dimeric organization, as revealed by its crystal structure, and includes four subunits (chains A-D) with specific colors indicating different chains. The enzyme's activity is regulated post-translationally, but its pathophysiological significance in humans remains underexplored. Multiple orthologs of the NADK gene are present in various organisms, illustrating its evolutionary conservation and importance across different species.

Specifications

Antigen NADK
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene NADK
Gene Accession No. O95544
Gene Alias 4432404C02Rik; BC004012; dJ283E3.1; FLJ13052; hypothetical protein LOC513419; LOW QUALITY PROTEIN: NAD kinase; NAD kinase; Nadk; Poly(P)/ATP NAD kinase; ppnk; Putative inorganic polyphosphate/ATP-NAD kinase (Poly(P)/ATP NAD kinase)
Gene Symbols NADK
Host Species Rabbit
Immunogen synthetic peptide directed towards the middle region of human NADK (aa 374-423).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 65220
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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