Invitrogen™ MRPL24 Polyclonal Antibody

Description

Immunogen sequence: ERVRVSTRSG RIIPKPEFPR ADGIVPETWI DGPKDTSVED ALERTYVPCL KTLQEEVMEA MGIKETRKYK KVYW Highest antigen sequence indentity to the following orthologs: Rat - 89%, Mouse - 91%.

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which is more than twice the size of its E. coli counterpart. Sequence analysis identified two transcript variants that encode the same protein.