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PeproTech Mouse RANKL (Soluble) ELISA Development Kit (ABTS), PeproTech®

Catalog No. 900K233K
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10 x 96 Tests
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900K233K 10 x 96 Tests
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Catalog No. 900K233K Supplier PeproTech Supplier No. 900K233K

Description

ELISA

900-K233K consists of: 900-K233 (capture antibody, detection antibody, and protein standard), and AVIDIN-60UL (avidin HRP-conjugate). Mouse RANKL (RANK Ligand) ABTS ELISA Development Kit contains the key components required for the quantitative measurement of natural and/or recombinant mouse RANKL (RANK Ligand) in a sandwich ELISA format. Mouse RANKL (RANK Ligand) ABTS ELISA Development Kit contains enough material to assay the target cytokine in at least 1,000 ELISA plate wells. The ABTS ELISA Buffer Kit (Product # 900-K00), sold separately, is recommended to be used in conjunction with this ABTS ELISA Development Kit for optimal performance. This buffer kit contains all the necessary components to assay ten 96-well ELISA plates (included) and contains detailed handling instructions.

This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.

Specifications

Accession Number O35235
Assay Range Lot-specific
Assay Sensitivity Lot-specific
Conjugate HRP
Immunoassay Kit Format Sandwich ELISA Kit
Product Type ELISA
Protein Family Growth Factors & Receptors
Target Species Mouse
For Use With (Equipment) Absorbance Microplate Reader
Gene Alias CD254; H-RANK-L; hRANKL2; Ly109l; M-Rank-L; ODF; OPG; OPG ligand; OPGL; OPTB2; Osteoclast differentiation factor; osteoprotegerin ligand; Rankl; rank-l; receptor activator of NF-kappaB ligand; receptor activator of nuclear factor kappa B ligand; receptor activator of nuclear factor kappa-B ligand; RP11-86N24.2; sOdf; srankl; TNF-related activation-induced cytokine; Tnfsf11; TNLG6B; Trance; tumor necrosis factor (ligand) superfamily member 11; tumor necrosis factor (ligand) superfamily, member 11; tumor necrosis factor ligand 6B; tumor necrosis factor ligand superfamily member 11; Tumor necrosis factor ligand superfamily member 11, membrane form; Tumor necrosis factor ligand superfamily member 11, soluble form; tumor necrosis factor superfamily member 11; tumor necrosis factor-related activation-induced cytokineCD254; H-RANK-L; hRANKL2; Ly109l; M-Rank-L; ODF; OPG; OPG ligand; OPGL; OPTB2; Osteoclast differentiation factor; osteoprotegerin ligand; Rankl; rank-l; receptor activator of NF-kappaB ligand; receptor activator of nuclear factor kappa B ligand; receptor activator of nuclear factor kappa-B ligand; RP11-86N24.2; sOdf; srankl; TNF-related activation-induced cytokine; Tnfsf11; TNLG6B; Trance; tumor necrosis factor (ligand) superfamily member 11; tumor necrosis factor (ligand) superfamily, member 11; tumor necrosis factor ligand 6B; tumor necrosis factor ligand superfamily member 11; Tumor necrosis factor ligand superfamily member 11, membrane form; Tumor necrosis factor ligand superfamily member 11, soluble form; tumor necrosis factor superfamily member 11; tumor necrosis factor-related activation-induced cytokine;
Gene ID (Entrez) 21943
Gene Symbol TNFSF11
Kit Contents This Mouse RANKL (RANK Ligand) ELISA Kit includes Capture Antibody, Detection Antibody, Protein Standard, and HRP-conjugate. The HRP-conjugate is packaged separately., Detection Antibody, Protein Standard, HRP-conjugate
Label or Dye Biotin
Quantity 10 x 96 Tests
Regulatory Status RUO
Shipping Condition Room temperature
Storage Requirements Refer to product documentation for component specific storage temperature.
Target RANKL (RANK Ligand)
Test Time 1 hr 45 min
Total Assay Time 24 hr 30 min
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