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Gibco™ Mouse Noggin, Animal-Free Recombinant Protein, PeproTech®

Catalog No. p-7245757
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Quantity:
100 μg
2 x 500 μg
20 μg
500 μg
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Catalog No. Quantity
AF25038100 100 μg
AF2503801M 2 x 500 μg
AF2503820UG 20 μg
AF25038500 500 μg
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Catalog No. AF25038100 Supplier Gibco™ Supplier No. AF25038100UG
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Description

Recombinant Protein

AF-250-38-1MG will be provided as 2 x 500 μg (AF-250-38-500UG). Recombinant Murine Noggin is a 46.4 kDa disulfide-linked homodimer consisting of two 206 amino acid polypeptide chains. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Noggin is involved in numerous developmental processes, such as neural tube fusion and joint formation. The morphogenesis of organs is initiated by a downgrowth from a layer of epithelial stem cells. This process is achieved through the receipt of signals from 1) a WNT protein (WNT3A) to stabilize beta-catenin; and 2) Noggin, which is a bone morphogenetic protein inhibitor. Noggin mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) have been identified, which have multiple joint fusion as their principal defect.

Specifications

Accession Number P97466
For Use With (Application) Functional Assay
Formulation protein with no preservative
Gene ID (Entrez) 18121
Molecular Weight (g/mol) 46.4 kDa
Name Mouse Noggin, Animal-Free
Quantity 100 μg
Source E. coli
Regulatory Status RUO
Endotoxin Concentration <0.1 EU/ μg
Gene Alias NOG; Noggin; Noggin precursor; noggin; LOW QUALITY PROTEIN: noggin; SYM1; symphalangism 1 (proximal); SYNS1; SYNS1A
Common Name Noggin
Gene Symbol NOG
Biological Activity Determined by its ability to inhibit 5.0 ng/ml of BMP-4 induced alkaline phosphatase production by ATDC5 chondrogenic cells. The expected ED50 for this effect is 1.0-2.0 ng/ml of Noggin.
Conjugate Unconjugated
Recombinant Recombinant
Sequence MQHYLHIRPA PSDNLPLVDL IEHPDPIFDP KEKDLNETLL RSLLGGHYDP GFMATSPPED RPGGGGGPAG GAEDLAELDQ LLRQRPSGAM PSEIKGLEFS EGLAQGKKQR LSKKLRRKLQ MWLWSQTFCP VLYAWNDLGS RFWPRYVKVG SCFSKRSCSV PEGMVCKPSK SVHLTVLRWR CQRRGGQRCG WIPIQYPIIS ECKCSC
Content And Storage -20°C
Expression System E. coli
Form Lyophilized
Purity or Quality Grade ≥ 98% by SDS-PAGE gel and HPLC analyses.
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