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Invitrogen™ Mouse IL-6 Recombinant Protein

Catalog No. ENRMIL6I
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20 μg
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Catalog No. Quantity
ENRMIL6I 20 μg
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Catalog No. ENRMIL6I Supplier Invitrogen™ Supplier No. RMIL6I

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Description

Recombinant Protein

Mature mouse IL-6 was expressed in Pichia pastoris, X-33. GenBank Accession # NP_112445, amino acids 25 - 211. For protein verification, the expressed protein was N-terminal sequenced and begins with the following 10 amino acids: FPTSQVRRGD. Purity is >95% by SDS-PAGE analyses. Use: For in vitro applications. A dose-response assay should be performed to determine the optimal concentration for specific experiments. Reconstitution and Dilution: Store lyophilized material at 4°C. Reconstitute in 0.5 mL of distilled or deionized water. Dilute in a buffer-containing carrier protein, aliquot, and store at or below -70°C, avoiding multiple freeze-thaw cycles. PBS with 1% BSA or a neutral media containing <10% FCS are suitable buffers.

IL-6 is a gene that encodes a cytokine that plays a role in inflammation and the maturation of B cells. The protein produced by this gene is an endogenous pyrogen that can induce fever in people with autoimmune diseases or infections. The gene is primarily expressed at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Elevated levels of the encoded protein have been found in virus infections, including COVID-19 (disease caused by SARS-CoV-2). Diseases associated with IL6 include Kaposi Sarcoma and Rheumatoid Arthritis, Systemic Juvenile.

Specifications

Accession Number P08505
For Use With (Application) Bioactivity
Formulation PBS with no preservative
Gene ID (Entrez) 16193
Molecular Weight (g/mol) 21.7 kDa
Name Mouse IL-6
Purification Method Purified
Quantity 20 μg
Storage Requirements 4°C
Regulatory Status RUO
Gene Alias B-cell differentiation factor; B-cell hybridoma growth factor; B-cell stimulatory factor 2; BSF2; BSF-2; CDF; CHIL-6; CTL differentiation factor; cytokine; HGF; H-IL-6; HSF; hybridoma growth factor; Ifnb2; IFN-beta-2; Il6; IL-6; ILg6; ILN; interferon beta-2; Interleukin; interleukin 6; Interleukin 6 (interferon, beta 2); interleukin 6 precursor; interleukin BSF-2; interleukin HP-1; Interleukin6; Interleukin-6; interleukin-6 precursor; interleukin-6 protein; M-IL-6; prointerleukin 6; R-IL-6
Common Name IL-6
Gene Symbol Il6
Product Type Protein
Conjugate Unconjugated
Recombinant Recombinant
Sequence Mouse IL-6, amino acids 25-211 (Accession # NP_112445)
Expression System P. pastoris
Form Lyophilized
Purity or Quality Grade >95% by SDS-PAGE
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