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Gibco™ Mouse IL-4 Recombinant Protein

Catalog No. p-5232758
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10 μg
25 μg
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Catalog No. Quantity
PMC0045 10 μg
PMC0046 25 μg
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Catalog No. PMC0045 Supplier Gibco™ Supplier No. PMC0045
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Description

Recombinant Protein

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Lyophilized mIL-4 should be reconstituted in sterile, 10 mM HAc not less than 100 μg/mL, which can then be further diluted to other aqueous solutions. For long term storage, it is recommended to add a carrier protein, such as 0.1% HSA or BSA. Storage: This lyophilized preparation is stable at room temperature for 3 weeks, but should be stored desiccated below -18°C. Upon reconstitution, the preparation is stable at 4°C for up to 1 week, but should be stored below -18°C for long term storage. Avoid repeated freeze/thaw cycles.

Interleukin-4 (IL-4) is a pleiotropic, immune-modulatory cytokine produced by activated T cells, and serves as a ligand for interleukin 4 receptor. IL-4 has been found to have the broadest range of actions. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play an important role in mediating the immune regulatory signal of IL-4. The IL-4 gene, IL-3, IL-5, IL-13, and CSF2 form a cytokine gene cluster on chromosome 5q. In particular, IL-4 is located in close proximity to IL13 on the chromosome. Further, the IL-4 gene, IL13 and IL5 are found to be coordinated by several long-range regulatory elements over a 120 kilobase range on the chromosome. IL-4 delta 2 is a known splice variant of IL-4.

Specifications

Accession Number P07750
For Use With (Application) Bioactivity
Formulation PBS with no preservative; pH 7.4
Gene ID (Entrez) 16189
Molecular Weight (g/mol) 13.5 kDa
Name Mouse IL-4
pH Range 7.4
Purification Method Purified
Quantity 10 μg
Storage Requirements -20°C
Regulatory Status RUO
Gene Alias B cell growth factor 1; B_cell stimulatory factor 1; B-cell growth factor 1; B-cell IgG differentiation factor; B-cell stimulatory factor 1; BCGF1; BCGF-1; binetrakin; BSF1; BSF-1; cytokine; H-IL-4; IGG1 induction factor; IL2; IL4; Il-4; Il4e12; ILN; Interleukin; interleukin 4; interleukin 4 variant 2; interleukin 4 variant IL-4delta2; interleukin 4 variant IL-4delta3; interleukin 4 variant IL-4int2A; interleukin 4 variant IL-4int3A; interleukin 4 variant IL-4int3B; Interleukin4; interleukin-4; interleukin-4 precursor; lymphocyte stimulatory factor 1; MGC79402; M-IL-4; Pitrakinra
Common Name IL-4
Gene Symbol Il4
Biological Activity ED50 = 2 ng/mL; determined by the dose-dependent proliferation of mouse HT-2 cells.
Product Type Protein
Conjugate Unconjugated
Species Mouse
Recombinant Recombinant
Sequence MHIHGCDKNH LREIIGILNE VTGEGTPCTE MDVPNVLTAT KNTTESELVC RASKVLRIFY LKHGKTPCLK KNSSVLMELQ RLFRAFRCLD SSISCTMNES KSTSLKDFLE SLKSIMQMDY S
Content And Storage -20°C
Activity ED50 ≤ 2 ng/mL; determined by the dose-dependent proliferation of mouse HT-2 cells.
Shipping Condition Approved for shipment on Wet or Dry Ice
Expression System E. coli
Protein Family Cytokines & Receptors
Protein Form Recombinant, Ligand
Form Lyophilized
Protein Subtype Interleukins
Research Category Immunology, Stem Cell Research, Inflammation
Product Line Gibco
Purity or Quality Grade >96% by SDS-PAGE and RP-HPLC
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