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Gibco™ Mouse GDNF, Animal-Free Recombinant Protein, PeproTech®
Description
The functional murine GDNF ligand is a disulfide-linked homodimer consisting of two 15.1 kDa polypeptide chains called monomers. Each monomer contains seven conserved cysteine residues, including Cys-101, which is used for inter-chain disulfide bridging, and others that are involved in the intramolecular ring formation known as the cysteine-knot configuration. The calculated molecular weight of Recombinant Murine GDNF is 30.2 kDa. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
GDNF is a glycosylated, disulfide-bonded homodimer molecule. It was first discovered as a potent survival factor for midbrain dopaminergic neurons and was then shown to rescue these neurons in animal models of Parkinson's disease. GDNF is about 100 times more efficient survival factor for spinal motor neurons than the neurotrophins. GDNF is a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.
Specifications
Specifications
| Accession Number | P48540 |
| For Use With (Application) | Functional Assay |
| Formulation | protein with no preservative |
| Gene ID (Entrez) | 14573 |
| Molecular Weight (g/mol) | 30.2 kDa |
| Name | Mouse GDNF, Animal-Free |
| Quantity | 100 μg |
| Source | E. coli |
| Regulatory Status | RUO |
| Endotoxin Concentration | <0.1 EU/ μg |
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