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Methotrexate
CAS: 59-05-2 | C20H22N8O5 | 454.447 g/mol
$259.49 - $1272.44
Chemical Identifiers
| CAS | 59-05-2 |
|---|---|
| Molecular Formula | C20H22N8O5 |
| Molecular Weight (g/mol) | 454.447 |
| MDL Number | MFCD00150847 |
| InChI Key | FBOZXECLQNJBKD-ZDUSSCGKSA-N |
| Synonym | methotrexate, abitrexate, rheumatrex, amethopterin, mexate, metatrexan, hdmtx, trexall, methylaminopterinum, antifolan |
| PubChem CID | 126941 |
| ChEBI | CHEBI:44185 |
| IUPAC Name | (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid |
| SMILES | CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O |
| Catalog Number | Mfr. No. | Quantity | Price | Quantity | |||||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Quantity | Price | Quantity | |||||
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AAJ63075MC
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Thermo Scientific Chemicals
J63075MC |
100 mg |
Each for $259.49
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AAJ6307503
|
Thermo Scientific Chemicals
J6307503 |
1 g |
Each for $1,272.44
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Description
Methotrexate is used as s cell cycle arresting agent that inhibits DHFR. It is used in treatment of cancer, autoimmune diseases, ectopic pregnancy, and for the induction of medical abortions. It acts by inhibiting the metabolism of folic acid. Methotrexate is one of the most effective and widely used medications for treating rheumatoid arthritis (RA) and other inflammatory types of arthritis. It is used as an anticancer drug.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
SolubilitySoluble in dilute HCl or dilute alkali hydroxide solutions (i.e. 0.1M NaOH). Insoluble in plain water.
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C. Keep away from strong oxidizing agents. Protect from light
Chemical Identifiers
| 59-05-2 | |
| 454.447 | |
| FBOZXECLQNJBKD-ZDUSSCGKSA-N | |
| 126941 | |
| (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acidShow More |
| C20H22N8O5 | |
| MFCD00150847 | |
| methotrexate, abitrexate, rheumatrex, amethopterin, mexate, metatrexan, hdmtx, trexall, methylaminopterinum, antifolanShow More | |
| CHEBI:44185 | |
| CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O |
Specifications
| 59-05-2 | |
| C20H22N8O5 | |
| 100 mg | |
| Hygroscopic; Light sensitive | |
| methotrexate, abitrexate, rheumatrex, amethopterin, mexate, metatrexan, hdmtx, trexall, methylaminopterinum, antifolan | |
| FBOZXECLQNJBKD-ZDUSSCGKSA-N | |
| (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid | |
| 126941 | |
| 454.44 | |
| Methotrexate |
| Yellow | |
| MFCD00150847 | |
| UN1544 | |
| 14,5985 | |
| Soluble in dilute HCl or dilute alkali hydroxide solutions (i;e; 0;1M NaOH); Insoluble in plain water. | |
| CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O | |
| 454.447 | |
| CHEBI:44185 | |
| Powder |
Safety and Handling
GHS H Statement
H301-H360-H315-H319
Toxic if swallowed.
May damage fertility or the unborn child.
Causes skin irritation.
Causes serious eye irritation.
P201-P202-P261-P264b-P270-P271-P280i-P281-P301+P310-P302+P352-P304+P340-P305+P351+P338-P308+P313-P330-P332+P313-P362-P501c
H301-H315-H319-H335-H340-H360FD
DOTInformation : Transport Hazard Class: 6.1; Packing Group: III; Proper Shipping Name: ALKALOIDS, SOLID, N.O.S.
EINECSNumber : 200-413-8
RTECSNumber : MA1225000
TSCA : Yes
Recommended Storage : Store at -20°C
RUO – Research Use Only