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Invitrogen™ Human MET [M1250T], His Tag Recombinant Protein

Catalog No. p-7121819
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100 μg
1 mg
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Catalog No. Quantity
PR7432A 100 μg
PV4272 1 mg
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Catalog No. PR7432A Supplier Invitrogen™ Supplier No. PR7432A
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Description

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Protein Form: Cytoplasmic

MET (cMET) is a receptor-like tyrosine kinase whose dysregulation has been linked to many types of human malignancies. After activation of the ligand, MET interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3. There interactions lead to the activation of signaling cascades including RAS-ERK, PI3, kinase-AKT, and PLCgamma-PKC. MET plays a role in embryonic development including gastrulation, development of muscles and neurons, angiogenesis, and kidney formation. It also plays a role in adults including wound healing, organ regeneration, and tissue remodeling. MET has been linked to cancers including gastric, renal, and breast; therefore, making it a target for cancer therapeutics and diagnostic testing.

Specifications

Concentration See Label
For Use With (Application) Kinase Assay
Formulation 50 mM tris HCl with 0.02% Triton X-100, 0.5 mM EDTA, 150 mM NaCl, 2 mM DTT, 50% glycerol and no preservative; pH 7.5
Molecular Weight (g/mol) 53.7 kDa
Name Human MET [M1250T], His Tag
Quantity 100 μg
Regulatory Status RUO - research use only
Common Name MET (M1250T Mutant)
KinaseFamily MET (HGFR) Kinase Family
Protein Length 956-1390; M1250T
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Protein Tag His-tag
Content And Storage -80°C, Avoid Freeze/Thaw Cycles
Expression System Insect cells
Form Liquid
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