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Melphalan, 94%, Thermo Scientific™
Melphalan, CAS # 148-82-3, belongs to the class of nitrogen mustards with anti-neoplastic activity.
Chemical Identifiers
| CAS | 148-82-3 |
|---|---|
| Molecular Formula | C13H18Cl2N2O2 |
| Molecular Weight (g/mol) | 305.2 |
| InChI Key | SGDBTWWWUNNDEQ-LBPRGKRZSA-N |
| Synonym | melphalan, alkeran, melfalan, phenylalanine mustard, l-sarcolysine, l-pam, l-sarcolysin, l-phenylalanine mustard, levofalan, p-l-sarcolysin |
| PubChem CID | 460612 |
| ChEBI | CHEBI:28876 |
| IUPAC Name | (2S)-2-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid |
| SMILES | C1=CC(=CC=C1CC(C(=O)O)N)N(CCCl)CCCl |
| Catalog Number | Mfr. No. | Quantity | Price | Quantity | |||||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Quantity | Price | Quantity | |||||
|
AC458650010
|
Thermo Scientific Chemicals
458650010 |
1g |
N/A
|
N/A | |||||
| Please call Customer Service at 1-800-234-7437 or send an email to help@thermofisher.com for assistance. | |||||||||
|
AC458650050
|
Thermo Scientific Chemicals
458650050 |
5g |
N/A
|
N/A | |||||
| Please call Customer Service at 1-800-234-7437 or send an email to help@thermofisher.com for assistance. | |||||||||
Description
This Thermo Scientific brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.
General Description
Melphalan is a phenylalanine derivative of nitrogen mustard with antineoplastic activity with the capacity to alkylate nucleic acids
Melphalan alkylates DNA at the N-7 position of guanine and induces DNA interstrand cross-linkages, resulting in the inhibition of DNA/RNA synthesis, inducing cytotoxicity against both dividing and non-dividing tumor cells
Applications
Melphalan has been used in in vitro experiments to treat multiple myeloma in cell lines and breast cancer cell lines
In in vivo experiments, using rats, it shows a potent therapeutic effect in cases of sarcomatous pulmonary metastases
Chemical Identifiers
| 148-82-3 | |
| 305.2 | |
| melphalan, alkeran, melfalan, phenylalanine mustard, l-sarcolysine, l-pam, l-sarcolysin, l-phenylalanine mustard, levofalan, p-l-sarcolysin | |
| CHEBI:28876 | |
| C1=CC(=CC=C1CC(C(=O)O)N)N(CCCl)CCCl |
| C13H18Cl2N2O2 | |
| SGDBTWWWUNNDEQ-LBPRGKRZSA-N | |
| 460612 | |
| (2S)-2-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid |
Specifications
| 148-82-3 | |
| 93% min. (HPLC) | |
| C13H18Cl2N2O2 | |
| 1g | |
| SGDBTWWWUNNDEQ-LBPRGKRZSA-N | |
| (2S)-2-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid | |
| 460612 | |
| 305.2 | |
| Melphalan |
| Authentic | |
| Glass Bottle | |
| (ClCH2CH2)2NC6H4CH2CH(NH2)COOH | |
| melphalan, alkeran, melfalan, phenylalanine mustard, l-sarcolysine, l-pam, l-sarcolysin, l-phenylalanine mustard, levofalan, p-l-sarcolysin | |
| C1=CC(=CC=C1CC(C(=O)O)N)N(CCCl)CCCl | |
| 305.2 | |
| CHEBI:28876 | |
| 94% |
Safety and Handling
GHS H Statement
Fatal if swallowed.
Fatal in contact with skin.
Fatal if inhaled.
Causes skin irritation.
Causes serious eye irritation.
May cause cancer.
Suspected of damaging fertility or the unborn child.<br/
GHS P Statement
IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.
IF ON SKIN: Wash with plenty of soap and water.
Take off contaminated clothing and wash before reuse.
IF IN EYES: Rinse cautio
GHS Signal Word: Danger
EINECSNumber : 205-726-3
RUO â Research Use Only