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Melphalan, 94%

Catalog No. p-7077747
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AC458650010 1 g
AC458650050 5 g
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Catalog No. AC458650010 Supplier Thermo Scientific Chemicals Supplier No. 458650010
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Description

Melphalan, CAS # 148-82-3, belongs to the class of nitrogen mustards with anti-neoplastic activity. | CAS: 148-82-3 | C13H18Cl2N2O2 | 305.2 g/mol

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Melphalan is a phenylalanine derivative of nitrogen mustard with antineoplastic activity with the capacity to alkylate nucleic acids
  • Melphalan alkylates DNA at the N-7 position of guanine and induces DNA interstrand cross-linkages, resulting in the inhibition of DNA/RNA synthesis, inducing cytotoxicity against both dividing and non-dividing tumor cells

Applications

  • Melphalan has been used in in vitro experiments to treat multiple myeloma in cell lines and breast cancer cell lines
  • In in vivo experiments, using rats, it shows a potent therapeutic effect in cases of sarcomatous pulmonary metastases

Chemical Identifiers

CAS 148-82-3
Molecular Formula C13H18Cl2N2O2
Molecular Weight (g/mol) 305.2
InChI Key SGDBTWWWUNNDEQ-LBPRGKRZSA-N
Synonym melphalan, alkeran, melfalan, phenylalanine mustard, l-sarcolysine, l-pam, l-sarcolysin, l-phenylalanine mustard, levofalan, p-l-sarcolysin
PubChem CID 460612
ChEBI CHEBI:28876
IUPAC Name (2S)-2-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid
SMILES C1=CC(=CC=C1CC(C(=O)O)N)N(CCCl)CCCl

Specifications

Melting Point 180.0°C
Infrared Spectrum Authentic
Assay Percent Range 93% min. (HPLC)
Packaging Glass Bottle
Linear Formula (ClCH2CH2)2NC6H4CH2CH(NH2)COOH
Quantity 1 g
Formula Weight 305.2
Percent Purity 94%
Chemical Name or Material Melphalan

Safety and Handling

Hazard Category GHS Signal Word: Danger
Hazard Statement GHS H Statement
Fatal if swallowed.
Fatal in contact with skin.
Fatal if inhaled.
Causes skin irritation.
Causes serious eye irritation.
May cause cancer.
Suspected of damaging fertility or the unborn child.<br/
Precautionary Statement GHS P Statement
IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.
IF ON SKIN: Wash with plenty of soap and water.
Take off contaminated clothing and wash before reuse.
IF IN EYES: Rinse cautio
EINECSNumber 205-726-3

RUO – Research Use Only