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Melatonin, 99+%
Melatonine, 99%, CAS # 73-31-4, is a hormone usually produced in the pineal gland and released into the blood. | CAS: 73-31-4 | C13H16N2O2 | 232.283 g/mol
Supplier: Thermo Scientific Chemicals J6245206
Description
Melatonin acts as a neurohormone that upregulates antioxidant enzymes and inhibits rat NOS1. It also acts as a particularly significant endogenous antioxidant. Melatonin is a rat NOS1 (nNOS) inhibitor. Melatonin is an activator of MEL-1A-R and MEL-1B-R.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
• Melatonine is a hormone produced by the pineal gland that shows several biological activities, including the somnolence, sleep-wake cycle, circadian rhythm, stress response, aging, and immunity activities
• It shows antioxidant, autocoid, paracoid, hormonal, anti- inflammatory and anti-apoptotic activities
Applications
• Melatonin shows neurohormonal activity and can upregulate antioxidant enzymes and inhibit rat NOS1
• Melatonin has been reported to be an activator of MEL-1A-R and MEL-1B-R
• The production and secretion of melatonine are dependent on beta-adrenergic receptor function
• During melatonine synthesis, the essential amino acid L-tryptophan is used as a precursor
• This compound inhibits apoptosis in immune cells and neurons, and enhances apoptotic cell death of cancer cells
• It can inhibit proliferation and metastasis of breast cancer cells by modulating Rho-associated kinase protein-1 expression
Specifications
| Melatonin | |
| 116°C to 120°C | |
| C13H16N2O2 | |
| 5 g | |
| 14,5816 | |
| Soluble in ethanol to at least 50mg/ml | |
| CC(=O)NCCC1=CNC2=C1C=C(C=C2)OC | |
| 232.283 | |
| CHEBI:16796 | |
| ≥99% |
| 73-31-4 | |
| White | |
| MFCD00005655 | |
| 205542 | |
| melatonin, melatonine, n-acetyl-5-methoxytryptamine, circadin, 5-methoxy-n-acetyltryptamine, n-2-5-methoxy-1h-indol-3-yl ethyl acetamide, melatol, melatonex, melovine | |
| DRLFMBDRBRZALE-UHFFFAOYSA-N | |
| N-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide | |
| 896 | |
| 232.28 | |
| Powder |
Chemical Identifiers
| 73-31-4 | |
| 232.283 | |
| DRLFMBDRBRZALE-UHFFFAOYSA-N | |
| 896 | |
| N-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide |
| C13H16N2O2 | |
| MFCD00005655 | |
| melatonin, melatonine, n-acetyl-5-methoxytryptamine, circadin, 5-methoxy-n-acetyltryptamine, n-2-5-methoxy-1h-indol-3-yl ethyl acetamide, melatol, melatonex, melovine | |
| CHEBI:16796 | |
| CC(=O)NCCC1=CNC2=C1C=C(C=C2)OC |
Safety and Handling
GHS H Statement
H361
Suspected of damaging fertility or the unborn child.
GHS P Statement
P281-P201-P202-P308+P313-P405-P501a
Use personal protective equipment as required.
Obtain special instructions before use.
Do not handle until all safety precautions have been read and understood.
IF exposed or concerned: Get medical advice/attention.
Store locked up.
Dispose of contents/container in accordance with local/regional/national/international regulations.
Warning
EINECSNumber : 200-797-7
RTECSNumber : AC5955000
TSCA : No
Recommended Storage : Keep cold
RUO – Research Use Only