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  6. Invitrogen™ MEKK3 Recombinant Rabbit Monoclonal Antibody (23GB2870)

Invitrogen™ MEKK3 Recombinant Rabbit Monoclonal Antibody (23GB2870)

Catalog No. MA552525
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100 μL
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MA552525 20 μL
MA552524 100 μL
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Catalog No. MA552525 Supplier Invitrogen™ Supplier No. MA552525
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Description

Rabbit Recombinant Monoclonal Antibody

MEKK3 Recombinant Monoclonal Antibody for Flow, ICC/IF, Western Blot

MAP3K3 (MEKK3) directly regulates MAPK8 and extracellular signal-regulated protein kinase (ERK) pathways by phosphorylating multiple MAP2Ks. Northern blot analysis revealed a 4. 6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Specifications

Antigen MEKK3
Applications Flow Cytometry, Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone 23GB2870
Concentration 0.6 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Map3k3
Gene Accession No. Q61084, Q99759
Gene Alias AW548911; MAP/ERK kinase kinase 3; MAP3K3; MAPK/ERK kinase kinase 3; MAPKKK3; MEK kinase 3; MEKK 3; Mekk3; mitogen activated protein kinase kinase kinase 3; mitogen-activated protein kinase kinase kinase 3; mKIAA4031
Gene Symbols Map3k3
Host Species Rabbit
Immunogen A synthesized peptide derived from human MEKK3 (1-47AA).
Purification Method Affinity chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 26406, 303604, 4215
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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