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Thermo Scientific™ Lovastatin, 98%
Lovastatin, CAS # 75330-75-5, is a cholesterol lowering compound and inhibitor of HMG-CoA reductase, a rate limiting enzyme in cholesterol synthesis.
Supplier: Thermo Scientific™ 458831000
Description
This Thermo Scientific brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.
General Description
Lovastatin is a compound that can lower cholesterol in vivo and in vitro by inhibiting HMG-CoA reductase, a rate limiting enzyme in cholesterol synthesis
Applications
• It blocks product ion of mevalonate, a critical compound in the production of cholesterol and isoprenoids
• It can increase cellular resistance to anticancer agents such as doxorubicin • It can induce apoptosis in myeloma cells
• It can cause cell cycle arrest in G1 and G2/M phase
• It also blocks PDGF receptor tyrosine phosphorylation and MAP kinase activation by PDGF
Specifications
| Lovastatin | |
| Authentic | |
| C24H36O5 | |
| 100g | |
| Solubility in water: insoluble. Other solubilities: less soluble in ethanol, soluble in chloroform and acetone | |
| CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@@H]12 | |
| 404.55 | |
| CHEBI:40303 | |
| 98% |
| 75330-75-5 | |
| 97.5% min. (HPLC) | |
| MFCD00072164 | |
| lovastatin, mevinolin, mevacor, monacolin k, lovalip, altoprev, lovalord, mevinacor, nergadan, 6alpha-methylcompactin | |
| PCZOHLXUXFIOCF-BXMDZJJMSA-N | |
| [(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate | |
| 53232 | |
| 404.54 |
Safety and Handling
GHS H Statement
May cause an allergic skin reaction.
Suspected of causing cancer.
Suspected of damaging the unborn child.
GHS P Statement
Wear protective gloves/protective clothing.
IF ON SKIN: Wash with plenty of soap and water.
Obtain special instructions before use.
IF exposed or concerned: Get medical advice/attention.
GHS Signal Word: Warning
RUO â Research Use Only