missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Chemicals
  4. Organic compounds
  5. Organoheterocyclic compounds
  6. Lactones
  7. Lovastatin, 97%

Lovastatin, 97%

Catalog No. p-7035086
Change view
missing translation for 'orderingAttributeHoverText'
Quantity:
25 g
5 g
Catalog No. Quantity
AAH5279206 5 g
AAH5279214 25 g
2 options

Catalog No. AAH5279206

Supplier: Thermo Scientific Chemicals H5279206

Only null left

Description

CAS: 75330-75-5 | C24H36O5 | 404.55 g/mol

Lovastatin is a cholesterol lowering drug and competitive inhibitor of HMG-CoA reductase, a rate limiting enzyme in cholesterol synthesis. Blocks the production of mevalonate, a critical compound in the production of cholesterol and isoprenoids. It increases cellular resistance to anticancer agents such as doxorubicin and induces apoptosis in myeloma cells. It causes cell cycle arrest in G1 and G2/M phases.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Lovastatin is a cholesterol lowering drug and competitive inhibitor of HMG-CoA reductase, a rate limiting enzyme in cholesterol synthesis. Blocks the production of mevalonate, a critical compound in the production of cholesterol and isoprenoids. It increases cellular resistance to anticancer agents such as doxorubicin and induces apoptosis in myeloma cells. It causes cell cycle arrest in G1 and G2/M phases.

Solubility
Soluble in DMSO (10 mg/ml), ethanol (10 mg/ml), methanol, chloroform, acetone, acetonitrile, DMF, and water (0.4 µg/ml).

Notes
Stable under recommended storage conditions. Incompatible with oxidizing agents and heat.

Chemical Identifiers

CAS 75330-75-5
Molecular Formula C24H36O5
Molecular Weight (g/mol) 404.55
MDL Number MFCD00072164
InChI Key PCZOHLXUXFIOCF-BXMDZJJMSA-N
Synonym lovastatin, mevinolin, mevacor, monacolin k, lovalip, altoprev, lovalord, mevinacor, nergadan, 6alpha-methylcompactin
PubChem CID 53232
ChEBI CHEBI:40303
IUPAC Name (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate
SMILES CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@@H]12

Specifications

Melting Point 175°C
Quantity 5 g
Solubility Information Soluble in DMSO (10mg/ml),ethanol (10mg/ml),methanol,chloroform,acetone,acetonitrile,DMF,and water (0.4 μg/ml).
Formula Weight 404.56
Percent Purity 97%
Chemical Name or Material Lovastatin

Safety and Handling

Hazard Category H317-H351-H361d
Hazard Statement GHS H Statement
H302-H315-H319-H335
Harmful if swallowed.
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.
Precautionary Statement P201-P202-P261-P272-P280g-P281-P302+P352-P308+P313-P333+P313-P363-P501c
RTECSNumber EK7907000
TSCA No
Recommended Storage Ambient temperatures

RUO – Research Use Only