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KIT [T670E] Recombinant Human Protein, Invitrogen™ DFS Item

KIT (c-KIT) is a proto-oncogene and a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Recombinant human KIT T670E (544-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

$614.00 - $9,380.00

Specifications

Host Species Human
Protein Tag GST Tag
Recombinant Yes
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Products 3
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PV6315 DFS Item
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Description

Description

KIT was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. KIT together with its ligand regulates growth and activation of a variety of hemopoietic and non-hemopoietic cells. Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Recently, deregulation of the KIT receptor TK by the prevalent activation loop mutation D816V has served as a focal point in therapeutic strategies aimed at curbing neoplastic mast cell growth.

  • Validated in LanthaScreen™ Kinase Binding Assay
  • Protocols available for simple use and optimized performance
  • Multiple pack sizes available for convenient use
Specifications

Specifications

Human
GST Tag
Yes
SDS