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Invitrogen™ K-Ras Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA588269
Description
Positive Samples: A-549, HeLa, Raji, Mouse spleen, Mouse lung, Rat brain; Cellular Location: Cell membrane, Cytoplasm, Cytoplasmic side, Lipid-anchor, cytosol Immunogen sequence: DEYDPTIEDS YRKQVVIDGE TCLLDILDTA GQEEYSAMRD QYMRTGEGFL CVFAINNTKS FEDIHHYREQ IKRVKDSEDV PMVLVGNKCD LPSRTVDTKQ AQDLARSYGI PFIETSAKTR QRVEDAFYTL VREIRQYRLK KISKEEKTPG CVKIKKCIIM.
K-RAS (GTPase KRas) belongs to the Ras oncogene family. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. It plays an important role in the regulation of cell proliferation and has a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes in colorectal cancer cells in a ZNF304-dependent manner. Mutations in the gene can result in leukemia acute myelogenous, leukemia juvenile myelomonocytic, Noonan Syndrome, gastric cancer, and cardiofaciocutaneous syndrome 2.Specifications
| K-Ras | |
| Polyclonal | |
| Unconjugated | |
| KRAS | |
| AI929937; cellular c-Ki-ras2; cellular c-Ki-ras2 proto-oncogene; CFC2; c-Ki-ras; c-Kirsten-ras protein; c-Kirsten-ras proto-oncogene; c-K-ras; c-K-ras2 protein; fa04e08; fc14b12; fc23g10; fj89d12; GTPase KRas; GTPase KRas, N-terminally processed; hypothetical protein LOC445289; K RAS; ki-Ras; Kirsten rat sarcoma oncogene 2, expressed; Kirsten rat sarcoma viral (Kras-2) oncogene homolog; Kirsten rat sarcoma viral oncogene; Kirsten rat sarcoma viral oncogene homolog; Kirsten rat sarcoma viral oncogene homologue 2 (active); KRAS; K-ras; K-Ras 2; K-ras p21 protein; KRAS proto-oncogene, GTPase; KRAS1; Kras2; Kras-2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; NS; NS3; oncogene KRAS2; p21; p21 protein; p21B; p21ras; PR310 c-K-ras oncogene; RALD; ras; ras p21; RASK; RASK2; ras-like protein; transforming protein p21; Unknown; v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog; v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; wu:fa04e08; wu:fc14b12; wu:fc23g10; wu:fj89d12; xRAS2; zgc:85725 | |
| Rabbit | |
| Affinity chromatography | |
| RUO | |
| 16653, 24525, 3845 | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| Liquid |
| ELISA, Western Blot, Immunocytochemistry, Western Blot | |
| 0.36 mg/mL | |
| PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3 | |
| P01116, P08644, P32883 | |
| KRAS | |
| A synthetic peptide corresponding to a sequence within amino acids 30-189 of human KRAS (NP_2035241). | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |