Invitrogen™ ILK Monoclonal Antibody (3A9)

Description

MA5-17099 targets ILK in indirect ELISA, FACS, IHC, and WB applications and shows reactivity with Human, Mouse, and Non-human primate samples. The MA5-17099 immunogen is purified recombinant fragment of human ILK (amino acids: 97-244) expressed in E. Coli. MA5-17099 detects ILK which has a predicted molecular weight of approximately 51.4kDa.

Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. This gene encodes a serine/threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.