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Invitrogen™ IL2RG Recombinant Rat Monoclonal Antibody (3E12)
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Catalog No. MA551816
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200 μg
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Catalog No. Quantity
MA551816 200 μg
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Catalog No. MA551816 Supplier Invitrogen™ Supplier No. MA551816
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Description

Rat Recombinant Monoclonal Antibody

This conformation-dependent antibody binds to the murine common gamma-chain, shared by the IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21 receptor complexes. It recognises an epitope located in a membrane-proximal portion of the common gamma-chain, near Arg-197 of domain 2. This antibody does not cross-react with COS7 cells transfected with rat common gamma-chain cDNA.

IL2RG is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder.

Specifications

Antigen IL2RG
Applications Flow Cytometry, Inhibition Assays, Immunoprecipitation
Classification Recombinant Monoclonal
Clone 3E12
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% ProClin 300
Gene IL2RG
Gene Accession No. P34902
Gene Alias [g]c; Ab2-183; CD132; CD132 antigen; CIDX; common cytokine receptor gamma chain; cytokine receptor common subunit gamma; gamma(c); gammaC; gc; IL-2 receptor subunit gamma; IL2R gamma; IL-2R subunit gamma; IL2RG; IL-2RG; IMD4; interleukin 2 receptor subunit gamma; interleukin 2 receptor, gamma; interleukin 2 receptor, gamma (severe combined immunodeficiency); interleukin 2 receptor, gamma chain; Interleukin-2 receptor subunit gamma; p64; SCIDX; SCIDX1
Gene Symbols IL2RG
Host Species Rat
Immunogen This antibody was raised by immunising Lewis rats with transfected rat myeloma cell line YB2/0, expressing murine cytoplasmic-tailless IL-2R common gamma-chain (YB2/0-myt).
Purification Method Protein A
Quantity 200 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16186
Target Species Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2b κ
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