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Invitrogen™ IL23R Polyclonal Antibody
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Catalog No. PIPA579490
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100 μg
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Catalog No. Quantity
PIPA579490 100 μg
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Catalog No. PIPA579490 Supplier Invitrogen™ Supplier No. PA579490
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Description

Rabbit Polyclonal Antibody

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: mouse brain tissue, mouse liver tissue, mouse kidney tissue.

IL-23R is a 629 aa, novel subunit of the receptor for cytokine IL23A/IL23 which pairs with the receptor molecule IL12RB1/IL12R beta 1and thus take part in IL23A signaling. Signal transduction analysis confirms that this protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. Alternative splicing results in six spliced isoforms of IL-23R. Reports suggest that IL-23R plays an important role in psoriasis pathogenesis and is also a potential therapeutic target in inflammatory bowel disease.

Specifications

Antigen IL23R
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 500 μg/mL
Conjugate Unconjugated
Formulation PBS with 4mg trehalose and 0.05mg sodium azide
Gene Il23r
Gene Accession No. Q8K4B4
Gene Alias IBD17; IL 23R; IL-23 receptor; IL23R; IL-23R; interleukin 23 receptor; interleukin 23 receptor-like; interleukin-23 receptor
Gene Symbols Il23r
Host Species Rabbit
Immunogen E. coli-derived mouse IL23 Receptor recombinant protein (Position: I25-D233).
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 209590, 689932
Target Species Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Lyophilized
Isotype IgG
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