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  6. Invitrogen™ IL-12 p40 Recombinant Rabbit Monoclonal Antibody (23GB5970)

Invitrogen™ IL-12 p40 Recombinant Rabbit Monoclonal Antibody (23GB5970)
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Catalog No. MA552960
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MA552960 100 μL
MA552961 20 μL
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Catalog No. MA552960 Supplier Invitrogen™ Supplier No. MA552960
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Description

Rabbit Recombinant Monoclonal Antibody

IL-12 p40 Recombinant Monoclonal Antibody for Flow, ICC/IF, Western Blot

IL12B (IL-12 p40) encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kDa cytokine receptor like subunit encoded by this gene, and a 35 kDa subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children.

Specifications

Antigen IL-12 p40
Applications Flow Cytometry, Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone 23GB5970
Concentration 0.4 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Il12b
Gene Accession No. P29460, P43432
Gene Alias CLMF; CLMF p35; CLMF p40; CLMF2; cytotoxic lymphocyte maturation factor 40 kDa subunit; Il12; IL12 p40; IL-12 p40 subunit; IL-12 subunit p35; IL-12 subunit p40; IL12, subunit p40; IL-12.p40; IL12A; IL-12A; Il12b; IL-12B; Il12p40; IL-12p40; IL-12p40 subunit; IMD28; IMD29; Interleukin; interleukin 12 p40 subunit; interleukin 12 subunit p40; interleukin 12, p40; interleukin 12B; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40); interleukin-12 beta chain; interleukin-12 beta chain precursor; interleukin-12 p40; interleukin-12 p40 chain; interleukin-12 p40 subunit; interleukin-12 subunit beta; interleukin-12 subunit p40; interleukin-12p40; interleukin-23 p40 subunit; natural killer cell stimulatory factor, 40 kD subunit; NK cell stimulatory factor chain 2; NKSF; NKSF1; NKSF2; p40; RP23-388G23.1
Gene Symbols Il12b
Host Species Rabbit
Immunogen A synthesized peptide derived from human IL12B (281-328AA).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16160, 3593, 64546
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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