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Gibco™ Human TSG Recombinant Protein, PeproTech® 
Recombinant Protein
Supplier: Gibco™ 12009100UG
Description
Recombinant Human TSG is a 198 amino acid, 22.2 kDa protein containing the BMP/TGF-beta binding portion of the full length TSG protein. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
TWSG1 may be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development.Specifications
| Q9GZX9 | |
| protein with no preservative | |
| 22.2 kDa | |
| 100 μg | |
| RUO | |
| 1810013J15Rik; 9030422N06Rik; AW552143; D17Ertd403e; PSEC0250; Tsg; Twg; twisted gastrulation BMP signaling modulator 1; twisted gastrulation homolog 1; twisted gastrulation homolog 1 (Drosophila); twisted gastrulation protein homolog 1; Twsg1 | |
| Twsg1 | |
| Unconjugated | |
| CNKALCASDV SKCLIQELCQ CRPGEGNCSC CKECMLCLGA LWDECCDCVG MCNPRNYSDT PPTSKSTVEE LHEPIPSLFR ALTEGDTQLN WNIVSFPVAE ELSHHENLVS FLETVNQPHH QNVSVPSNNV HAPYSSDKEH MCTVVYFDDC MSIHQCKISC ESMGASKYRW FHNACCECIG PECIDYGSKT VKCMNCMF | |
| E. coli | |
| ≥ 98% by SDS-PAGE gel and HPLC analyses. |
| Functional Assay | |
| 57045 | |
| Human TSG | |
| E. coli | |
| <1 EU/ μg | |
| TSG | |
| Determined by its ability to neutralize BMP-6-induced alkaline phosphatase production by ATDC chondrogenic cells. The expected ED50 for this effect is ≤ 2.0 ug/ml of TSG. | |
| Recombinant | |
| -20°C | |
| Lyophilized |