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Gibco™ Human TNF-RII (soluble) Recombinant Protein 
Recombinant Protein
Supplier: Gibco™ PHR3025
Description
Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute sTNF-RII in sterile, distilled water to a concentration of 0.1-1.0 mg/mL. Further dilutions should be made in aqueous buffers supplemented with carrier protein, such as 0.1-1.0% BSA. Do not vortex. This solution can be stored at 2°C to 8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein, such as 0.1% BSA and store in working aliquots at -20°C to -80°C. Storage: The lyophilized protein is stable at room temperature for 1 month, but should be kept at -20°C for long term storage. Working aliquots stored with a carrier protein are stable for at least 3 months at -20°C to -80°C. Avoid repeated freeze/thaw cycles.
TNFR2 (tumor necrosis factor receptor superfamily member 1B) is a receptor with high affinity for TNFSF2/TNF-alpha. It has a much lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. TNFR2 mediates most of the metabolic effects of TNF-alpha.Specifications
| P20333 | |
| 10mM sodium phosphate with 50mM NaCl and no preservative; pH 8 | |
| 18.9 kDa | |
| 8 | |
| 20 μg | |
| RUO | |
| CD120b; Etanercept; p75; p75 TNF receptor; p75 TNFR; p75TNFR; p80 TNF-alpha receptor; sCD120b; soluble CD120b; soluble TNFR1B variant 1; soluble TNFR2; sTNF R2; sTNFR 2; sTNFR2; TBP-2; TBPII; TNF receptor beta chain; TNF receptor superfamily member 1B; TNF-alphaR2; TNFalpha-R2; TNFBR; TNFR; TNFR II; Tnfr-1; TNFR1B; TNFR2; TNF-R2; Tnfr-2; TNF-R75; TNFR80; TNFRII; TNF-RII; TNF-R-II; TNFR-II; TNFRSF1B; tumor necrosis factor beta receptor; tumor necrosis factor binding protein 2; Tumor necrosis factor receptor; tumor necrosis factor receptor 2; Tumor necrosis factor receptor superfamily member 1B; Tumor necrosis factor receptor superfamily member 1b, membrane form; tumor necrosis factor receptor superfamily, member 1B; tumor necrosis factor receptor type II; Tumor necrosis factor-binding protein 2 | |
| Tnfrsf1b | |
| Protein | |
| Human | |
| Human TNF-RII recombinant protein contains 174 amino acids | |
| ED50 = 0.125 μg/mL; determined by the dose-dependent inhibition of TNF-alpha (0.25 ng/mL) mediated cytotoxicity in mouse L-929 cells. | |
| Approved for shipment on Wet or Dry Ice | |
| Cytokines & Receptors | |
| Lyophilized | |
| Immunology, Inflammation, Oncology, Signal Transduction | |
| ≥98% by SDS-PAGE and HPLC |
| Bioactivity | |
| 7133 | |
| Human TNF-RII (soluble) | |
| Purified | |
| -20°C | |
| <0.1 ng/μg | |
| TNFR2 | |
| ED50 = 0.125 μg/mL; determined by the dose-dependent inhibition of TNF-alpha (0.25 ng/mL) mediated cytotoxicity in mouse L-929 cells. | |
| Unconjugated | |
| Recombinant | |
| -20°C | |
| <0.1 ng/μg | |
| E. coli | |
| Recombinant, Ligand | |
| TNF (Tumor Necrosis Factor) | |
| Gibco™ |