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Gibco™ Human TL-1A, Animal-Free Recombinant Protein, PeproTech®

Numéro de catalogue. AF31023500
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20 μg
500 μg
1 mg
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Numéro de catalogue. Quantité
AF31023500 500 μg
AF31023100 100 μg
AF310231MG 1 mg
AF3102320UG 20 μg
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Numéro de catalogue. AF31023500 Fournisseur Gibco™ Code fournisseur AF31023500UG

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Description

Recombinant Protein

Recombinant Human TL-1A is a 22.1 kDa polypeptide of 195 amino acid residues. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. An additional isoform encoded by an alternatively spliced transcript variant has been reported but the sequence of this transcript has not been determined.

Spécifications

Numéro d'enregistrement O95150
À utiliser avec (application) Control, Bioactivity
Formule Protein with no preservative
ID du gène (Entrez) 9966
Poids moléculaire (g/mol) 22.1 kDa
Nom Human TL-1A, Animal-Free
Méthode de purification Purified
Quantité 500 μg
Sources E. coli
Conditions de stockage -20°C
Statut réglementaire RUO
Concentration en endotoxines <0.1 EU/μg
Alias du gène bM20K13.3 (tumor necrosis factor (ligand) superfamily, member 15); MGC129934; MGC129935; TL1; TL1A; TNF ligand-related molecule 1; TNF superfamily ligand TL1A; TNFSF15; TNLG1B; tumor necrosis factor (ligand) superfamily member 15; tumor necrosis factor (ligand) superfamily, member 15; tumor necrosis factor ligand 1B; tumor necrosis factor ligand superfamily member 15; Tumor necrosis factor ligand superfamily member 15, membrane form; Tumor necrosis factor ligand superfamily member 15, secreted form; tumor necrosis factor superfamily member 15; vascular endothelial cell growth inhibitor; vascular endothelial growth inhibitor; vascular endothelial growth inhibitor-192A; Vegi; VEGI192A
Nom usuel TL1A
Symbole de gène TNFSF15
Activité biologique Determined by its ability to stimulate IFN-gamma production by human PBMC co-stimulated with Human IL-12 and Human IL-18.
Type de produit Protein
Conjugué Unconjugated
Recombinant Recombinant
Séquence MQLRAQGEAS VQFQALKGQE FAPSHQQVYA PLRADGDKPR AHLTVVRQTP TQHFKNQFPA LHWEHELGLA FTKNRMNYTN KFLLIPESGD YFIYSQVTFR GMTSECSEIR QAGRPNKPDS ITVVITKVTD SYPEPTQLLM GTKSVCEVGS NWFQPIYLGA MFSLQEGDKL MVNVSDISLV DYTKEDKTFF GAFLL
Contenu et stockage -20°C
Activité Determined by its ability to stimulate IFN-gamma production by human PBMC co-stimulated with Human IL-12 and Human IL-18.
Système d’expression E. coli
Forme Lyophilized
Grade de qualité ou de pureté ≥ 98% by SDS-PAGE gel and HPLC analyses.
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