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eBioscience™ Human TGF beta 3, Recombinant Protein, Carrier-Free

Human Recombinant Protein

$2,434.55 - $7,147.05

Specifications

Name TGF beta 3
Recombinant Yes
Conjugate Unlabeled
Purity >98%
Purification Method SDS-PAGE and HPLC
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Products
Catalog Number Mfr. No. Quantity Price Quantity    

501123524

 
ebioscience™
34873482
100μg Each for $2,434.55

501123525

 
ebioscience™
34873485
500μg Each for $7,147.05
Description & Specifications

Specifications

Name TGF beta 3
Recombinant Yes
Conjugate Unlabeled
Purity >98%
Purification Method SDS-PAGE and HPLC
Source E. coli
For Use With (Application) Functional Assays
Molecular Weight 25.0kDa
Storage Requirements Store lyophilized protein at less than or equal to -20°C. Reconstituted protein solution can be stored with carrier-protein (e.g., 0.1% BSA) at less than or equal to -20°C.

Transforming growth factor beta 3 (TGF beta 3) is the third member of the transforming growth factor family of cytokines, which also includes TGF beta 1 and beta 2. These cytokines are secreted in precursor form consisting of a bioactive C-terminal domain attached to an N-terminal domain known as latency associated protein (LAP). Cleavage of LAP results in the mature protein, which functions as a disulfide-linked homodimer. As with all members of the family, TGF beta 3 is highly conserved across species, with mouse and human TGF beta 3 demonstrating 100% sequence homology and cross-species activity.

The members of this family can be expressed by most cell types and exert pleiotropic effects, which include the suppression of B- and T-cell effector activity, mediation of tissue healing, and suppression of tumor proliferation. The promotion of CD4+CD25+ T-cell expansion is a newly discovered function of the TGF beta cytokines, and indicates an important role in the protection against autoimmunity.