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Invitrogen™ Human SPATA13 (aa 172-281) Control Fragment Recombinant Protein

Catalog No. RP98018
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100 μL
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Catalog No. Quantity
RP98018 100 μL
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Catalog No. RP98018 Supplier Invitrogen™ Supplier No. RP98018
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Description

Recombinant Protein

Highest antigen sequence indentity to the following orthologs: Mouse (54%), Rat (54%). This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-59096 (PA5-59096. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.

Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. [UniProt]

Specifications

Accession Number Q96N96
Concentration ≥5.0 mg/mL
For Use With (Application) Blocking Assay, Control
Formulation 1 M urea, PBS with no preservative; pH 7.4
Gene ID (Entrez) 221178
Name Human SPATA13 (aa 172-281) Control Fragment
Quantity 100 μL
Regulatory Status RUO
Gene Alias adenomatous polyposis coli stimulated exchange factor 2; APC-stimulated guanine nucleotide exchange factor 2; ARHGEF29; ASEF2; C79050; ESTM11; mFLJ00298; Spata13; spermatogenesis associated 13; spermatogenesis-associated protein 13; spt13; X83327
Common Name SPATA13
Gene Symbol Spata13
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Protein Tag His-ABP-tag
Sequence ALRPAEWGTLDGSDLEDTDDAFQRSTHRSRSLRRAYGLGRICLLDAPQNHATPTIATGQVPAVCEILVRDPENNSMGYRRSKSTDNLAFLKKSSFKRKSTSNLADLRTAH
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Expression System E. coli
Form Liquid
Purity or Quality Grade >80% by SDS-PAGE and Coomassie blue staining
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