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Gibco™ Human R-Spondin-3 Recombinant Protein, PeproTech®

Catalog No. 12044250UG
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Catalog No. Quantity
12044250UG 250 μg
12044100UG 100 μg
120441MG 1 mg
1204420UG 20 μg
12044500UG 500 μg
120445UG 5 μg
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Catalog No. 12044250UG Supplier Gibco™ Supplier No. 12044250UG

Description

Recombinant Protein

Recombinant Human R-Spondin-3 is a 26.9 kDa protein consisting of 240 amino acid residues. Due to glycosylation, R-Spondin-3 migrates at an apparent molecular weight of approximately 37.0 kDa by SDS PAGE analysis under reducing conditions. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

RSPO3 is a member of the R-spondin family and plays a role in the regulation of Wnt (wingless-type MMTV integration site family)/beta-catenin and Wnt/planar cell polarity (PCP) signaling pathways, which are involved in development, cell growth and disease pathogenesis. RSPO3 has been shown to be involved in regulating the balance between angioblast and blood cell specification during embryonic vasculogenesis and angiogenesis and may be involved in tumor development.

Specifications

Accession Number Q9BXY4
For Use With (Application) Control, Bioactivity
Formulation Protein with no preservative
Gene ID (Entrez) 84870
Molecular Weight (g/mol) 26.9 kDa
Name Human R-Spondin-3
Purification Method Purified
Quantity 250 μg
Source CHO cells
Storage Requirements -20°C
Regulatory Status RUO
Endotoxin Concentration <1 EU/μg
Gene Alias 2810459H04Rik; AW742308; Cabriolet; cristin 1; Cristin1; cristin-1; cysteine-rich and single thrombospondin domain-containing protein 1; hPWTSR; hRspo3; Nucleopondin; protein with TSP type-1 repeat; PWTSR; RGD1563246; Roof plate-specific spondin-3; Rspo3; R-spondin 3; R-spondin 3 homolog; R-spondin 3 homolog (Xenopus laevis); R-spondin 3-like protein; R-spondin-3; Thrombospondin type-1 domain-containing protein 2; thrombospondin, type I, domain 2; thrombospondin, type I, domain containing 2; Thsd2; Unknown (protein for MGC:137973)
Common Name RSPO3
Gene Symbol RSPO3
Biological Activity R-Spondin-3 enhances BMP-2-mediated differentiation of MC3T3-E1 cells. The expected ED50 for this effect is 0.8 -2.0 ug/ml
Product Type Protein
Conjugate Unconjugated
Recombinant Recombinant
Sequence MHPNVSQGCQ GGCATCSDYN GCLSCKPRLF FALERIGMKQ IGVCLSSCPS GYYGTRYPDI NKCTKCKADC DTCFNKNFCT KCKSGFYLHL GKCLDNCPEG LEANNHTMEC VSIVHCEVSE WNPWSPCTKK GKTCGFKRGT ETRVREIIQH PSAKGNLCPP TNETRKCTVQ RKKCQKGERG KKGRERKRKK PNKGESKEAI PDSKSLESSK EIPEQRENKQ QQKKRKVQDK QKSVSVSTVH
Content And Storage -20°C
Activity R-Spondin-3 enhances BMP-2-mediated differentiation of MC3T3-E1 cells. The expected ED50 for this effect is 0.8 -2.0 ug/ml.
Expression System CHO cells
Form Lyophilized
Purity or Quality Grade ≥ 95% by SDS-PAGE gel and HPLC analyses.
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