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Invitrogen™ Human PLK4 (aa 208-342) Control Fragment Recombinant Protein

Catalog No. RP105743
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100 μL
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Catalog No. Quantity
RP105743 100 μL
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Catalog No. RP105743 Supplier Invitrogen™ Supplier No. RP105743

Description

Recombinant Protein

Highest antigen sequence indentity to the following orthologs: Mouse (84%), Rat (84%). This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-110825 (PA5-110825. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.

PLK4 or polo-like kinase 4 is a member of the polo family of serine/threonine protein kinases which localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. The overexpression of PLK4 triggered the simultaneous formation of multiple procentrioles around each preexisting centriole which resulting in centriole amplification and thus, Plk4-induced centriole biogenesis in human cells. The reduced Plk4 gene dosage increases the probability of mitotic errors and cancer development.

Specifications

Accession Number O00444
Concentration ≥5.0 mg/mL
For Use With (Application) Blocking Assay, Control
Formulation 1 M urea, PBS with no preservative; pH 7.4
Gene ID (Entrez) 10733
Name Human PLK4 (aa 208-342) Control Fragment
Quantity 100 μL
Gene Alias 1700028H20; AI385771; MCCRP2; PLK4; PLK-4; polo like kinase 4; polo-like kinase 4; SAK; serine/threonine kinase 18; serine/threonine-protein kinase 18; Serine/threonine-protein kinase PLK4; serine/threonine-protein kinase Sak; Snk akin kinase; Stk18
Common Name PLK4
Gene Symbol PLK4
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Protein Tag His-ABP-tag
Sequence RPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMSRNSSTKSKDLGTVEDSIDSGHATISTAITASSSTSISGSLFDKRRLLIGQPLPNKMTVFPKNKSSTDFSSSGDGNS
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Expression System E. coli
Form Liquid
Purity or Quality Grade >80% by SDS-PAGE and Coomassie blue staining
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