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Invitrogen™ Human Pellino 2 (aa 297-321) Control Fragment Recombinant Protein

Catalog No. RP100026
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100 μL
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Catalog No. Quantity
RP100026 100 μL
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Catalog No. RP100026 Supplier Invitrogen™ Supplier No. RP100026
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Description

Recombinant Protein

Highest antigen sequence indentity to the following orthologs: Mouse (96%), Rat (96%). This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-62754 (PA5-62754. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.

E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1. [UniProt]

Specifications

Accession Number Q9HAT8
Concentration ≥5.0 mg/mL
For Use With (Application) Blocking Assay, Control
Formulation 1 M urea, PBS with no preservative; pH 7.4
Gene ID (Entrez) 57161
Name Human Pellino 2 (aa 297-321) Control Fragment
Quantity 100 μL
Regulatory Status RUO
Gene Alias AW047589; BB129927; E3 ubiquitin-protein ligase pellino homolog 2; Peli2; pellino 2; pellino E3 ubiquitin protein ligase family member 2; pellino homolog 2; pellino-2; protein pellino homolog 2; RGD1565884; RING-type E3 ubiquitin transferase pellino homolog 2
Common Name Pellino 2
Gene Symbol Peli2
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Protein Tag His-ABP-tag
Sequence NRKEVVEEKQPWAYLSCGHVHGYHN
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Expression System E. coli
Form Liquid
Purity or Quality Grade >80% by SDS-PAGE and Coomassie blue staining
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