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Gibco™ Human Oncostatin M (209 aa) Recombinant Protein, PeproTech®

Catalog No. 30010T10UG
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Catalog No. Quantity
30010T10UG 10 μg
30010T100UG 100 μg
30010T1MG 1 mg
30010T250UG 250 μg
30010T2UG 2 μg
30010T500UG 500 μg
30010T50UG 50 μg
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Catalog No. 30010T10UG Supplier Gibco™ Supplier No. LS30010T10UG

Please call Customer Service at 1-800-234-7437 or send an email to help@thermofisher.com for assistance.

Description

Recombinant Protein

Recombinant Human Oncostatin M is a 23.6 kDa protein, containing 209 amino acid residues. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Oncostatin M (OSM) is a growth and differentiation factor that participates in the regulation of neurogenesis, osteogenesis and hematopoiesis. Produced by activated T cells, monocytes and Kaposi's sarcoma cells, OSM can exert both stimulatory and inhibitory effects on cell proliferation. It stimulates the proliferation of fibroblasts, smooth muscle cells and Kaposi's sarcoma cells, but inhibits the growth of some normal and tumor cell lines. It also promotes cytokine release (e.g. IL-6, GM-CSF and G-CSF) from endothelial cells, and enhances the expression of low-density lipoprotein receptors in hepatoma cells. OSM shares several structural and functional characteristics with LIF, IL-6, and CNTF.

Specifications

Accession Number P13725
For Use With (Application) Control, Bioactivity
Formulation Protein with no preservative
Gene ID (Entrez) 5008
Molecular Weight (g/mol) 23.6 kDa
Name Human Oncostatin M (209 aa)
Purification Method Purified
Quantity 10 μg
Source E. coli
Storage Requirements -20°C
Regulatory Status RUO
Endotoxin Concentration <1 EU/μg
Gene Alias MGC20461; OncoM; oncostatin M; oncostatin-M; OSM
Common Name Oncostatin M
Gene Symbol OSM
Biological Activity The ED50 as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 10^5 units/mg
Product Type Protein
Conjugate Unconjugated
Recombinant Recombinant
Sequence AAIGSCSKEY RVLLGQLQKQ TDLMQDTSRL LDPYIRIQGL DVPKLREHCR ERPGAFPSEE TLRGLGRRGF LQTLNATLGC VLHRLADLEQ RLPKAQDLER SGLNIEDLEK LQMARPNILG LRNNIYCMAQ LLDNSDTAEP TKAGRGASQP PTPTPASDAF QRKLEGCRFL HGYHRFMHSV GRVFSKWGES PNRSRRHSPH QALRKGVRR
Content And Storage -20°C
Activity The ED50 as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 10^5 units/mg.
Expression System E. coli
Form Lyophilized
Purity or Quality Grade ≥ 98% by SDS-PAGE gel and HPLC analyses.
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