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Gibco™ Human/Mouse/Rat Myostatin Recombinant Protein, PeproTech®

Catalog No. 12000100ug
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Catalog No. Quantity
12000100UG 100 μg
1200010UG 10 μg
120001MG 1 mg
12000250UG 250 μg
120002UG 2 μg
12000500UG 500 μg
1200050UG 50 μg
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Catalog No. 12000100UG Supplier Gibco™ Supplier No. 12000100UG
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Description

Recombinant Protein

The amino acid sequence of mature myostatin is extremely conserved across species, and is the same in murine, rat, chicken, turkey, porcine, and human. Myostatin is expressed as the C-terminal part of a precursor polypeptide, which also contains a short N-terminal signal sequence for secretion, and a propeptide of 243 amino acids. After dimerization of this precursor, the covalent bonds between the propeptide and the mature ligand are cleaved by furin-type proteases. However, the resulting two proteins remain associated through non-covalent interactions, and are secreted as a latent complex. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

The protein encoded by this gene is a member of the bone morphogenetic protein family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. This gene is thought to encode a secreted protein which negatively regulates skeletal muscle growth.

Specifications

Accession Number O08689, O14793, O35312
For Use With (Application) Functional Assay
Formulation protein with no preservative
Gene ID (Entrez) 17700, 2660, 29152
Molecular Weight (g/mol) 25 kDa
Name Human/Mouse/Rat Myostatin
Quantity 100 μg
Source E. coli
Regulatory Status RUO
Endotoxin Concentration <1 EU/ μg
Gene Alias Cmpt; compact; Gdf8; GDF-8; growth differentiation factor 8; growth/differentiation factor 8; H-Myo-Propeptide; H-Myostatin; MSLHP; MSTN; Myostatin
Common Name Myostatin
Gene Symbol Mstn
Biological Activity Determined by its ability to inhibit the proliferation of MPC-11 cells. The expected ED50 for this effect is 17.0-25.0 ng/ml
Conjugate Unconjugated
Recombinant Recombinant
Sequence DFGLDCDEHS TESRCCRYPL TVDFEAFGWD WIIAPKRYKA NYCSGECEFV FLQKYPHTHL VHQANPRGSA GPCCTPTKMS PINMLYFNGK EQIIYGKIPA MVVDRCGCS
Content And Storage -20°C
Expression System E. coli
Form Lyophilized
Purity or Quality Grade ≥ 98% by SDS-PAGE gel and HPLC analyses.
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