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PeproTech Human/Mouse/Rat BMP-2 ELISA Development Kit (TMB), PeproTech®

Catalog No. 900T255K
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10 x 96 Tests
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900T255K 10 x 96 Tests
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Catalog No. 900T255K Supplier PeproTech Supplier No. 900T255K

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Description

ELISA

900-T255K consists of: 900-T255 (capture antibody, detection antibody, and protein standard), and HRP-17UL (streptavidin HRP-conjugate). Human/Mouse/Rat BMP-2 TMB ELISA Development Kit contains the key components required for the quantitative measurement of natural and/or recombinant human/mouse/rat BMP-2 in a sandwich ELISA format. Human/Mouse/Rat BMP-2 TMB ELISA Development Kit contains enough material to assay the target cytokine in at least 1,000 ELISA plate wells. The TMB ELISA Buffer Kit (Product # 900-T00), sold separately, is recommended to be used in conjunction with this TMB ELISA Development Kit for optimal performance. This buffer kit contains all the necessary components to assay ten 96-well ELISA plates (included) and contains detailed handling instructions.

Bone Morphogenic Proteins (BMP) are members of the TGF-beta superfamily that affect bone and cartilage formation (Hogan 1996, Reddi 1998 and Francis-West et al. 1999). Mature BMPs are 30-38 kDa proteins that assume a TGF-beta -like cysteine knot configuration. Lovostatin increases bone formation by turning on the bmp-2 gene (Mundy et al. 1999). BMPs stimulate the production of specific bone matrix proteins and alter stromal cell and osteoclast proliferation (Macias et al. 1999, Lecanda et al. 1997). BMPs may also be an important factor for development of the viscera, with roles in cell proliferation, apoptosis, differentiation, and morphogenesis (Hogan 1996, Dale and Wardle 1999). BMPs appear to be responsible for normal dorsal/ventral patterning. Like TGF-beta, BMPs bind to a type II receptor, which then recruits the transducing type I receptor unit, activating the Smad protein signaling pathway (Massague 1994, Derynck 1997, Attisano 1993).

Specifications

Accession Number P12643, P21274, P49001
Assay Range Lot-specific
Assay Sensitivity Lot-specific
Conjugate HRP
Immunoassay Kit Format Sandwich ELISA Kit
Product Type ELISA
Protein Family Growth Factors & Receptors
Target Species Human, Mouse, Rat
For Use With (Equipment) Absorbance Microplate Reader
Gene Alias 2610024H22Rik; AI467020; AL117858; AW546137; BB189135; BDA2; BMP; BMP2; BMP-2; BMP2A; BMP-2A; BMPRII; BMPR-II; Bone morphogenetic; Bone morphogenetic protein; Bone morphogenetic protein 2; bone morphogenetic protein 2 precursor (BMP-2) (BMP-2A); bone morphogenetic protein 2A; H-BMP-2; morphogen2610024H22Rik; AI467020; AL117858; AW546137; BB189135; BDA2; BMP; BMP2; BMP-2; BMP2A; BMP-2A; BMPRII; BMPR-II; Bone morphogenetic; Bone morphogenetic protein; Bone morphogenetic protein 2; bone morphogenetic protein 2 precursor (BMP-2) (BMP-2A); bone morphogenetic protein 2A; H-BMP-2; morphogen;
Gene ID (Entrez) 12156, 29373, 650
Gene Symbol BMP2
Kit Contents This Human/Mouse/Rat BMP-2 ELISA Kit includes Capture Antibody, Detection Antibody, Protein Standard, and HRP-conjugate. The HRP-conjugate is packaged separately., Detection Antibody, Protein Standard, HRP-conjugate
Label or Dye Biotin
Quantity 10 x 96 Tests
Regulatory Status RUO
Shipping Condition Room temperature
Storage Requirements Refer to product documentation for component specific storage temperature.
Target BMP-2
Test Time 1 hr 45 min
Total Assay Time 24 hr 30 min
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