missing translation for 'onlineSavingsMsg'
Learn More
Learn More
Gibco™ Human/Mouse/Rat Activin A Recombinant Protein, PeproTech®
Recombinant Protein
Supplier: Gibco™ 12014P01M
Description
120-14P-1MG will be provided as 2 x 500 μg (120-14P-500UG). Recombinant Human/Murine/Rat Activin A is a 26.0 kDa disulfide-linked homodimer of two betaA chains, each containing 116 amino acid residues. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Activin A mutations are associated with fibrodysplasia ossificans progressive.Specifications
| P08476, P18331, Q04998 | |
| Protein with no preservative | |
| 26 kDa | |
| Purified | |
| CHO cells | |
| RUO | |
| activin A; activin beta-A chain; BMP7; BMP-7; Bone morphogenetic protein 7; EDF; Eptotermin alfa; erythroid differentiation factor; erythroid differentiation protein; follicle-stimulating hormone-releasing protein; FRP; FSH-releasing protein; INHB; Inhba; inhibin B subunit; inhibin beta A chain; inhibin beta A protein; inhibin beta A subunit; inhibin beta-A; inhibin beta-A-subunit; inhibin beta-subunit; inhibin subunit beta A; inhibin, beta A; inhibin, beta A (activin A, activin AB alpha polypeptide); Inhibin, beta-1; OP1; OP-1; Osteogenic protein 1; unnamed protein product | |
| Inhba | |
| Protein | |
| Recombinant | |
| -20°C | |
| CHO cells | |
| ≥ 95% by SDS-PAGE gel and HPLC analyses. |
| Control, Bioactivity | |
| 16323, 29200, 3624 | |
| Human/Mouse/Rat Activin A | |
| 2 x 500 μg | |
| -20°C | |
| <1 EU/μg | |
| Activin A | |
| Determined by its ability to inhibit the proliferation of mouse MPC-11 cells. The expected ED50 is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 10^5 units/mg | |
| Unconjugated | |
| GLECDGKVNI CCKKQFFVSF KDIGWNDWII APSGYHANYC EGECPSHIAG TSGSSLSFHS TVINHYRMRG HSPFANLKSC CVPTKLRPMS MLYYDDGQNI IKKDIQNMIV EECGCS | |
| Determined by its ability to inhibit the proliferation of mouse MPC-11 cells. The expected ED50 is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 10^5 units/mg. | |
| Lyophilized |