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Invitrogen™ Human MINT3 (aa 63-141) Control Fragment Recombinant Protein

Catalog No. RP98872
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100 μL
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RP98872 100 μL
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Catalog No. RP98872 Supplier Invitrogen™ Supplier No. RP98872

Description

Recombinant Protein

Highest antigen sequence indentity to the following orthologs: Mouse (70%), Rat (70%). This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-61037 (PA5-61037. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.

The munc-18 interacting protein (Mint) protein family is a group of evolutionarily conserved adaptor proteins that function in membrane transport and organization. In mammals, there exist three mint isoforms, Mint1, 2, and 3. Although there is little amino acid sequence conservation in the amino-terminal half, the carboxy-terminal half of these proteins is highly conserved. Within this conserved portion there exists a phosphotyrosine-binding (PTB) and a PSD-95/DLG-A/ZO-1 (PDZ) domain, which function as protein interaction modules. Mint1 and 2 appear to be expressed exclusively in the brain and are found to bind to Munc18, an essential component of the synaptic vesicle fusion machinery. Mint3 is ubiquitously expressed in all tissues and is expressed at the lowest levels in the brain and testis. Studies show that mint3 does not interact with munc-18. Mint3 has been found to interact with the Alzheimer's Disease-related amyloid precursor protein (APP) and does so through its PTB and PDZ domains. It has been suggested that mint3 links APP to other transport machinery components, thereby regulating it transport, endocytosis, and metabolism. Abnormal APP metabolism has been shown to be the cause of an early-onset type of Alzheimer's disease.

Specifications

Accession Number O96018
Concentration ≥5.0 mg/mL
For Use With (Application) Blocking Assay, Control
Formulation 1 M urea, PBS with no preservative; pH 7.4
Gene ID (Entrez) 9546
Name Human MINT3 (aa 63-141) Control Fragment
Quantity 100 μL
Gene Alias Adapter protein X11 gamma; amyloid beta (A4) precursor protein-binding family A member 3 ( x 11-like 2); amyloid beta (A4) precursor protein-binding, family A, member 3 ( x 11-like 2); amyloid beta (A4) precursor protein-binding, family A, member 3; amyloid beta (A4) precursor protein-binding, family A, member 3 ( x 11-like 2); amyloid beta A4 precursor protein-binding family A member 3; amyloid beta precursor protein binding family A member 3; Amyloid-beta A4 precursor protein-binding family A member 3; Apba3; AW208791; lin 10; lin-10; MGC:15815; Mint 3; MINT3; mint-3; Neuronal Munc18-1-interacting protein 3; neuron-specific X11L2 protein; phosphotyrosine-binding/-interacting domain (PTB)-bearing protein; X11 gamma; X11L2; X11-like 2 protein
Common Name MINT3
Gene Symbol APBA3
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Protein Tag His-ABP-tag
Sequence QFEALPGDLVGPSPGGAPCPLHIATGHGLASQEIADAHGLLSAEAGRDDLLGLLHCEECPPSQTGPEEPLEPAPRLLQP
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Expression System E. coli
Form Liquid
Purity or Quality Grade >80% by SDS-PAGE and Coomassie blue staining
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