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Invitrogen™ Human IL-6R (soluble) Recombinant Protein

Catalog No. PIRP75604
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100 μg
1 mg
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PIRP75604 1 mg
PIRP75603 100 μg
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Catalog No. PIRP75604 Supplier Invitrogen™ Supplier No. RP75604

Description

Recombinant Protein

This product contains purified recombinant human IL-6 Soluble Receptor protein with an N-terminal hexahistidine tag. This product may be used as a positive control in many immunological assays.

Interleukin 6 receptor (IL6R), also known as CD126 (Cluster of Differentiation 126), is a type I cytokine receptor. This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.

Specifications

Accession Number P08887
Concentration 0.35 mg/mL
For Use With (Application) Bioactivity, Western Blot
Formulation 20mM tris HCl with 50% glycerol, 5mM DTT and no preservative; pH 8
Gene ID (Entrez) 3570
Name Human IL-6R (soluble)
pH Range 8
Purification Method Purified
Quantity 1 mg
Source E. coli
Immunogen N/A
Storage Requirements -20°C, Avoid Freeze/Thaw Cycles
Regulatory Status RUO
Gene Alias CD126; CD126 antigen; gp80; IL-6 Receptor; il-6 receptor alpha; IL-6 receptor alpha chain; IL-6 receptor subunit alpha; IL6Q; IL6R; IL-6R; IL-6R 1; IL-6R subunit alpha; IL6R1; IL-6R-1; Il6ra; IL-6RA; IL-6R-alpha; IL6RQ; ILN; Interleukin; interleukin 6 receptor; interleukin 6 receptor, alpha; interleukin-6 receptor subunit alpha; Membrane glycoprotein 80; MGC104991
Common Name IL-6 Receptor (CD126)
Gene Symbol IL6R
Product Type Protein
Conjugate Unconjugated
Species E. coli
Recombinant Recombinant
Protein Tag His-tag
Sequence Amino acids Leu20-Gln357 containing an N-terminal His-tag
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Expression System E. coli
Form Liquid
Protein Subtype Recombinant
Purity or Quality Grade >95%, by SDS-PAGE under reducing conditions
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