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Gibco™ Human IL-35 Recombinant Protein, PeproTech®

Catalog No. 2003710UG
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50 μg
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Catalog No. Quantity
2003710UG 10 μg
20037250UG 5 x 50 μg
200372UG 2 μg
20037500UG 10 x 50 μg
2003750UG 50 μg
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Catalog No. 2003710UG Supplier Gibco™ Supplier No. LS2003710UG
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Description

Recombinant Protein

200-37-100UG will be provided as 2 x 50 μg (200-37-50UG). 200-37-1MG will be provided as 20 x 50 μg (200-37-50UG). 200-37-250UG will be provided as 5 x 50 μg (200-37-50UG). 200-37-500UG will be provided as 5 x 100 μg (200-37-50UG). Recombinant Recombinant Human IL-35 expressed in HEK293 cells contains 406 amino acid residues and has a calculated molecular weight of 45.8 kDa. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

IL-35, or Interleukin 35 is a cytokine belonging to the IL12 family, that is produced by regulatory T cells. It is a dimeric protein composed of IL-12-alpha and IL-27-beta chains. Members of this class of cytokines are important in influencing T helper cell differentiation and supressing inflammatory response. IL-35 is known to induce proliferation of regulatory T cells, and reduce the activity of helper Th17 cells.

Specifications

Accession Number P29459
For Use With (Application) Functional Assay
Formulation protein with no preservative
Gene ID (Entrez) 3592
Molecular Weight (g/mol) 45.8 kDa
Name Human IL-35
Quantity 10 μg
Source HEK293 cells
Regulatory Status RUO
Endotoxin Concentration <1 EU/ μg
Gene Alias CLMF; CLMF p35; cytokine receptor; cytotoxic lymphocyte maturation factor 1, p35; cytotoxic lymphocyte maturation factor 35 kDa subunit; EBI3; EBV-induced gene 3 protein; Epstein-Barr virus induced 3; Epstein-Barr virus induced gene 3; epstein-Barr virus-induced gene 3 protein; IL-12 subunit p35; IL-12, subunit p35; IL12A; IL-12 A; IL12p35; IL27 subunit; IL-27 subunit beta; IL27B; IL-27 B; il35; IL35 subunit; ILN; Interleukin; interleukin 12, p35; interleukin 12 A; interleukin 12 A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35); interleukin-12 alpha chain; interleukin-12 subunit alpha; Interleukin-27 subunit beta; Interleukin-35; NF cell stimulatory factor chain 1; NFSK; NK cell stimulatory factor chain 1; NKSF1; P35
Common Name IL-35
Gene Symbol IL12A
Biological Activity Measured by its ability to inhibit proliferative activity of PBMCs.
Conjugate Unconjugated
Recombinant Recombinant
Sequence Alpha Subunit: RNLPVATPDP GMFPCLHHSQ NLLRAVSNML QKARQTLEFY PCTSEEIDHE DITKDKTSTV EACLPLELTK NESCLNSRET SFITNGSCLA SRKTSFMMAL CLSSIYEDLK MYQVEFKTMN AKLLMDPKRQ IFLDQNMLAV IDELMQALNF NSETVPQKSS LEEPDFYKTK IKLCILLHAF RIRAVTIDRV MSYLNAS Beta Subunit: RKGPPAALTL PRVQCRASRY PIAVDCSWTL PPAPNSTSPV SFIATYRLGM AARGHSWPCL QQTPTSTSCT ITDVQLFSMA PYVLNVTAVH PWGSSSSFVP FITEHIIKPD PPEGVRLSPL AERQLQVQWE PPGSWPFPEI FSLKYWIRYK RQGAARFHRV GPIEATSFIL RAVRPRARYY VQVAAQDLTD YGELSDWSLP ATATMSLGK
Content And Storage -20°C
Expression System HEK293 cells
Form Lyophilized
Purity or Quality Grade ≥ 90% by SDS-PAGE gel and HPLC analyses.
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