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Invitrogen™ Human IL-10 ProQuantum Immunoassay Kit

Catalog No. A35590
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96 Tests
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A35590 96 Tests
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Catalog No. A35590 Supplier Invitrogen™ Supplier No. A35590

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Description

ELISA

IL-10 encodes a protein that acts as a cytokine and is primarily produced by monocytes, with some production by lymphocytes. This cytokine has various effects on immunoregulation and inflammation, including down-regulating the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. Additionally, IL-10 can block NF-kappa B activity and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice have suggested that this cytokine is an essential immunoregulator in the intestinal tract. Mutations in this gene have been associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. Diseases associated with IL10 include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1.

Specifications

Accession Number P22301
Assay Range 0.064-5000 pg/mL
Assay Sensitivity <0.05 pg/mL
Content And Storage Contains assay dilution buffer, antibody-conjugate A, antibody-conjugate B, antibody-conjugate dilution buffer, standard, master mix, and ligase. Store at -5°C to -30°C.
Conjugate FAM
Immunoassay Kit Format Proximity-based Immunoassay
Product Type ProQuantum
Sample Type Plasma, Serum, Supernatant
Target Species Human
For Use With (Equipment) qPCR Instruments
Gene Alias CSIF; cytokine; Cytokine synthesis inhibitory factor; GVHDS; H-IL-10; il 10; IL10; IL-10; IL-10 precursor; IL10A; IL10X; ILN; Interleukin; interleukin 10; Interleukin10; interleukin-10; MGC126450; MGC126451; RP11-262N9.1; T-cell growth inhibitory factor; TGIFCSIF; cytokine; Cytokine synthesis inhibitory factor; GVHDS; H-IL-10; il 10; IL10; IL-10; IL-10 precursor; IL10A; IL10X; ILN; Interleukin; interleukin 10; Interleukin10; interleukin-10; MGC126450; MGC126451; RP11-262N9.1; T-cell growth inhibitory factor; TGIF;
Gene ID (Entrez) 3586
Gene Symbol IL10
Kit Contents Assay Dilution Buffer, Antibody-Conjugate A, Antibody-Conjugate B, Antibody-Conjugate Dilution Buffer, Standard, Master Mix, Ligase, Fetal Bovine Serum, Antibody-Conjugate A, Antibody-Conjugate B, Antibody-Conjugate Dilution Buffer, Standard, Master Mix, Ligase, Fetal Bovine Serum
Label or Dye FAM™
Quantity 96 Tests
Regulatory Status RUO
Sample Volume Plasma 2-5 μL, Serum 2-5 μL, Supernatant 2-5 μL
Shipping Condition Dry Ice
Storage Requirements -20°C
Target IL-10
Test Time 30 min
Total Assay Time 2 hr
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