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Invitrogen™ Human HNF1A (aa 264-339) Control Fragment Recombinant Protein

Catalog No. RP102658
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100 μL
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RP102658 100 μL
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Catalog No. RP102658 Supplier Invitrogen™ Supplier No. RP102658

Description

Recombinant Protein

Highest antigen sequence indentity to the following orthologs: Mouse (92%), Rat (92%). This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-83263 (PA5-83263. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.

This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation.

Specifications

Accession Number P20823
Concentration ≥5.0 mg/mL
For Use With (Application) Blocking Assay, Control
Formulation 1 M urea, PBS with no preservative; pH 7.4
Gene ID (Entrez) 6927
Name Human HNF1A (aa 264-339) Control Fragment
Quantity 100 μL
Regulatory Status RUO
Gene Alias AI323641; albumin proximal factor; hepatic nuclear factor 1; hepatic nuclear factor-1-alpha; hepatocyte nuclear factor 1; hepatocyte nuclear factor 1-alpha; Hepatocyte nuclear factor 1-alpha-A; HNF1; Hnf-1; hnf-1 alpha; HNF1 homeobox A; HNF1 homeobox A L homeolog; HNF1 homeobox A S homeolog; HNF1[a]; hnf1a; Hnf-1 A; hnf1-a; hnf1a.L; hnf1a.S; HNF-1 A-A; hnf1a-a; hnf1a-b; Hnf1alpha; HNF-1-alpha; HNF1-alpha; HNF-1-alpha-A; I79_010330; IDDM20; interferon production regulator factor; LFB1; LF-B1; LF-B1 hepatic nuclear factor (HNF1): albumin proximal factor also TCF1; LF-B1, hepatic nuclear factor (HNF1): albumin proximal factor, also TCF1; lfb1a; LFB1a1; Liver-specific transcription factor LF-B1; MODY3; TCF1; Tcf-1; TCF-1-A; tcf1-a; transcription factor 1; Transcription factor 1 hepatic; Transcription factor 1, hepatic; transcription factor 1, transcription factor LFB1 /HNF1; transcription factor 1-A; XELAEV_18010473mg; XLFB1; XLFB1a; XLFB1b
Common Name HNF1A
Gene Symbol Hnf1a
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Protein Tag His-ABP-tag
Sequence VYNWFANRRKEEAFRHKLAMDTYSGPPPGPGPGPALPAHSSPGLPPPALSPSKVHGVRYGQPATSETAEVPSSSGG
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Expression System E. coli
Form Liquid
Purity or Quality Grade >80% by SDS-PAGE and Coomassie blue staining
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